Rushing
- *ProBowl, +1st-tm All-Pro
| Games | Rushing | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 1 | O.J. Simpson*+ | 1973 | 26 | BUF | RB | 14 | 14 | 332 | 2003 | 12 | 80 | 6.0 | 143.1 | 7 |
| 2 | O.J. Simpson*+ | 1975 | 28 | BUF | RB | 14 | 14 | 329 | 1817 | 16 | 88 | 5.5 | 129.8 | 7 |
| 3 | James Cook* | 2025 | 26 | BUF | RB | 17 | 17 | 309 | 1621 | 12 | 64 | 5.2 | 95.4 | 6 |
| 4 | O.J. Simpson*+ | 1976 | 29 | BUF | RB | 14 | 13 | 290 | 1503 | 8 | 75 | 5.2 | 107.4 | 6 |
| 5 | Thurman Thomas* | 1992 | 26 | BUF | RB | 16 | 16 | 312 | 1487 | 9 | 44 | 4.8 | 92.9 | 6 |
| 6 | Travis Henry* | 2002 | 24 | BUF | RB | 16 | 16 | 325 | 1438 | 13 | 34 | 4.4 | 89.9 | 11 |
| 7 | Thurman Thomas*+ | 1991 | 25 | BUF | RB | 15 | 15 | 288 | 1407 | 7 | 33 | 4.9 | 93.8 | 5 |
| 8 | Travis Henry | 2003 | 25 | BUF | RB | 15 | 15 | 331 | 1356 | 10 | 64 | 4.1 | 90.4 | 7 |
| 9 | Thurman Thomas* | 1993 | 27 | BUF | RB | 16 | 16 | 355 | 1315 | 6 | 27 | 3.7 | 82.2 | 6 |
| 10 | Thurman Thomas*+ | 1990 | 24 | BUF | RB | 16 | 16 | 271 | 1297 | 11 | 80 | 4.8 | 81.1 | 6 |
| 11 | LeSean McCoy* | 2016 | 28 | BUF | RB | 15 | 15 | 234 | 1267 | 13 | 75 | 5.4 | 84.5 | 3 |
| 12 | O.J. Simpson*+ | 1972 | 25 | BUF | RB | 14 | 14 | 292 | 1251 | 6 | 94 | 4.3 | 89.4 | 8 |
| 13 | Willis McGahee | 2005 | 24 | BUF | RB | 16 | 15 | 325 | 1247 | 5 | 27 | 3.8 | 77.9 | 1 |
| 14 | Thurman Thomas* | 1989 | 23 | BUF | RB | 16 | 16 | 298 | 1244 | 6 | 38 | 4.2 | 77.8 | 7 |
| 15 | C.J. Spiller* | 2012 | 25 | BUF | RB | 16 | 9 | 207 | 1244 | 6 | 62 | 6.0 | 77.8 | 3 |
| 16 | Joe Cribbs* | 1980 | 22 | BUF | RB | 16 | 16 | 306 | 1185 | 11 | 48 | 3.9 | 74.1 | 16 |
| 17 | LeSean McCoy* | 2017 | 29 | BUF | RB | 16 | 16 | 287 | 1138 | 6 | 48 | 4.0 | 71.1 | 3 |
| 18 | Joe Cribbs* | 1983 | 25 | BUF | RB | 16 | 16 | 263 | 1131 | 3 | 45 | 4.3 | 70.7 | 6 |
| 19 | Willis McGahee | 2004 | 23 | BUF | RB | 16 | 11 | 284 | 1128 | 13 | 41 | 4.0 | 70.5 | 4 |
| 20 | O.J. Simpson*+ | 1974 | 27 | BUF | RB | 14 | 14 | 270 | 1125 | 3 | 41 | 4.2 | 80.4 | 7 |
| 21 | Antowain Smith | 1998 | 26 | BUF | RB | 16 | 14 | 300 | 1124 | 8 | 30 | 3.7 | 70.3 | 5 |
| 22 | James Cook* | 2023 | 24 | BUF | RB | 17 | 13 | 237 | 1122 | 2 | 42 | 4.7 | 66.0 | 4 |
| 23 | Marshawn Lynch | 2007 | 21 | BUF | RB | 13 | 13 | 280 | 1115 | 7 | 56 | 4.0 | 85.8 | 2 |
| 24 | Greg Bell* | 1984 | 22 | BUF | RB | 16 | 15 | 262 | 1100 | 7 | 85 | 4.2 | 68.8 | 5 |
| 25 | Joe Cribbs* | 1981 | 23 | BUF | RB | 15 | 15 | 257 | 1097 | 3 | 35 | 4.3 | 73.1 | 12 |
| 26 | Cookie Gilchrist*+ | 1962 | 27 | BUF | FB | 14 | 14 | 214 | 1096 | 13 | 44 | 5.1 | 78.3 | 7 |
| 27 | Thurman Thomas | 1994 | 28 | BUF | RB | 15 | 15 | 287 | 1093 | 7 | 29 | 3.8 | 72.9 | 1 |
| 28 | Fred Jackson | 2009 | 28 | BUF | RB | 16 | 11 | 237 | 1062 | 2 | 43 | 4.5 | 66.4 | 4 |
| 29 | Terry Miller | 1978 | 22 | BUF | RB | 16 | 16 | 238 | 1060 | 7 | 60 | 4.5 | 66.3 | 8 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 30 | Marshawn Lynch* | 2008 | 22 | BUF | RB | 15 | 15 | 250 | 1036 | 8 | 50 | 4.1 | 69.1 | 2 |
| 31 | Thurman Thomas | 1996 | 30 | BUF | RB | 15 | 15 | 281 | 1033 | 8 | 36 | 3.7 | 68.9 | 1 |
| 32 | James Cook* | 2024 | 25 | BUF | RB | 16 | 16 | 207 | 1009 | 16 | 65 | 4.9 | 63.1 | 1 |
| 33 | Thurman Thomas | 1995 | 29 | BUF | RB | 14 | 14 | 267 | 1005 | 6 | 49 | 3.8 | 71.8 | 6 |
| 34 | Willis McGahee | 2006 | 25 | BUF | RB | 14 | 14 | 259 | 990 | 6 | 57 | 3.8 | 70.7 | 4 |
| 35 | Cookie Gilchrist*+ | 1964 | 29 | BUF | FB | 14 | 14 | 230 | 981 | 6 | 67 | 4.3 | 70.1 | 6 |
| 36 | Cookie Gilchrist* | 1963 | 28 | BUF | FB | 14 | 14 | 232 | 979 | 12 | 32 | 4.2 | 69.9 | 8 |
| 37 | Fred Jackson | 2011 | 30 | BUF | RB | 10 | 10 | 170 | 934 | 6 | 80 | 5.5 | 93.4 | 2 |
| 38 | C.J. Spiller | 2013 | 26 | BUF | RB | 15 | 10 | 202 | 933 | 2 | 77 | 4.6 | 62.2 | 4 |
| 39 | Fred Jackson | 2010 | 29 | BUF | RB | 16 | 13 | 222 | 927 | 5 | 39 | 4.2 | 57.9 | 5 |
| 40 | LeSean McCoy* | 2015 | 27 | BUF | RB | 12 | 12 | 203 | 895 | 3 | 48 | 4.4 | 74.6 | 2 |
| 41 | Fred Jackson | 2013 | 32 | BUF | RB | 16 | 6 | 206 | 890 | 9 | 59 | 4.3 | 55.6 | 3 |
| 42 | Greg Bell | 1985 | 23 | BUF | FB/RB | 16 | 15 | 223 | 883 | 8 | 77 | 4.0 | 55.2 | 8 |
| 43 | Thurman Thomas | 1988 | 22 | BUF | RB | 15 | 15 | 207 | 881 | 2 | 37 | 4.3 | 58.7 | 9 |
| 44 | Devin Singletary | 2021 | 24 | BUF | RB | 17 | 16 | 188 | 870 | 7 | 46 | 4.6 | 51.2 | 5 |
| 45 | Antowain Smith | 1997 | 25 | BUF | RB | 16 | 0 | 194 | 840 | 8 | 56 | 4.3 | 52.5 | 4 |
| 46 | Jim Braxton | 1975 | 26 | BUF | FB | 14 | 14 | 186 | 823 | 9 | 29 | 4.4 | 58.8 | 7 |
| 47 | Devin Singletary | 2022 | 25 | BUF | RB | 16 | 16 | 177 | 819 | 5 | 33 | 4.6 | 51.2 | 3 |
| 48 | Devin Singletary | 2019 | 22 | BUF | RB | 12 | 8 | 151 | 775 | 2 | 38 | 5.1 | 64.6 | 4 |
| 49 | Bobby Burnett* | 1966 | 23 | BUF | HB | 14 | 14 | 187 | 766 | 4 | 32 | 4.1 | 54.7 | 3 |
| 50 | Josh Allen | 2021 | 25 | BUF | QB | 17 | 17 | 122 | 763 | 6 | 34 | 6.3 | 44.9 | 8 |
| 51 | Josh Allen* | 2022 | 26 | BUF | QB | 16 | 16 | 124 | 762 | 7 | 44 | 6.1 | 47.6 | 13 |
| 52 | O.J. Simpson | 1971 | 24 | BUF | RB | 14 | 14 | 183 | 742 | 5 | 46 | 4.1 | 53.0 | 5 |
| 53 | Travis Henry | 2001 | 23 | BUF | RB | 13 | 12 | 213 | 729 | 4 | 25 | 3.4 | 56.1 | 5 |
| 54 | Darick Holmes | 1995 | 24 | BUF | RB | 16 | 2 | 172 | 698 | 4 | 38 | 4.1 | 43.6 | 4 |
| 55 | O.J. Simpson* | 1969 | 22 | BUF | RB | 13 | 13 | 181 | 697 | 2 | 32 | 3.9 | 53.6 | 6 |
| 56 | Wray Carlton* | 1966 | 29 | BUF | FB | 14 | 14 | 156 | 696 | 6 | 23 | 4.5 | 49.7 | 4 |
| 57 | Jonathan Linton | 1999 | 25 | BUF | RB | 16 | 2 | 205 | 695 | 5 | 18 | 3.4 | 43.4 | 4 |
| 58 | Devin Singletary | 2020 | 23 | BUF | RB | 16 | 16 | 156 | 687 | 2 | 51 | 4.4 | 42.9 | 1 |
| 59 | Thurman Thomas | 1997 | 31 | BUF | RB | 16 | 16 | 154 | 643 | 1 | 24 | 4.2 | 40.2 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 60 | Joe Cribbs | 1982 | 24 | BUF | RB | 7 | 6 | 134 | 633 | 3 | 62 | 4.7 | 90.4 | 5 |
| 61 | Robb Riddick | 1986 | 29 | BUF | RB | 15 | 8 | 150 | 632 | 4 | 41 | 4.2 | 42.1 | 8 |
| 62 | Josh Allen | 2018 | 22 | BUF | QB | 12 | 11 | 89 | 631 | 8 | 45 | 7.1 | 52.6 | 8 |
| 63 | Kenneth Davis | 1991 | 29 | BUF | RB | 16 | 1 | 129 | 624 | 4 | 78 | 4.8 | 39.0 | 0 |
| 64 | Antowain Smith | 1999 | 27 | BUF | RB | 14 | 11 | 165 | 614 | 6 | 52 | 3.7 | 43.9 | 4 |
| 65 | Kenneth Davis | 1992 | 30 | BUF | RB | 16 | 0 | 139 | 613 | 6 | 64 | 4.4 | 38.3 | 5 |
| 66 | Keith Lincoln* | 1967 | 28 | BUF | HB | 14 | 14 | 159 | 601 | 4 | 28 | 3.8 | 42.9 | 3 |
| 67 | Frank Gore | 2019 | 36 | BUF | RB | 16 | 8 | 166 | 599 | 2 | 41 | 3.6 | 37.4 | 0 |
| 68 | Wray Carlton* | 1965 | 28 | BUF | HB | 14 | 14 | 156 | 592 | 6 | 80 | 3.8 | 42.3 | 2 |
| 69 | Shawn Bryson | 2000 | 24 | BUF | RB | 16 | 7 | 161 | 591 | 0 | 24 | 3.7 | 36.9 | 1 |
| 70 | Curtis Brown | 1978 | 24 | BUF | FB | 15 | 10 | 128 | 591 | 4 | 58 | 4.6 | 39.4 | 7 |
| 71 | Wayne Crow | 1962 | 24 | BUF | HB | 14 | 3 | 110 | 589 | 1 | 52 | 5.4 | 42.1 | 1 |
| 72 | Tyrod Taylor | 2016 | 27 | BUF | QB | 15 | 15 | 95 | 580 | 6 | 49 | 6.1 | 38.7 | 4 |
| 73 | Josh Allen* | 2025 | 29 | BUF | QB | 17 | 17 | 112 | 579 | 14 | 40 | 5.2 | 34.1 | 7 |
| 74 | Mike Gillislee | 2016 | 26 | BUF | RB | 15 | 1 | 101 | 577 | 8 | 44 | 5.7 | 38.5 | 1 |
| 75 | Curtis Brown | 1979 | 25 | BUF | FB | 15 | 15 | 172 | 574 | 1 | 25 | 3.3 | 38.3 | 10 |
| 76 | Darick Holmes | 1996 | 25 | BUF | RB | 16 | 1 | 189 | 571 | 4 | 37 | 3.0 | 35.7 | 2 |
| 77 | Fred Jackson | 2008 | 27 | BUF | RB | 16 | 3 | 130 | 571 | 3 | 32 | 4.4 | 35.7 | 3 |
| 78 | Tyrod Taylor* | 2015 | 26 | BUF | QB | 14 | 14 | 104 | 568 | 4 | 31 | 5.5 | 40.6 | 9 |
| 79 | C.J. Spiller | 2011 | 24 | BUF | RB | 16 | 11 | 107 | 561 | 4 | 38 | 5.2 | 35.1 | 2 |
| 80 | Curtis Brown | 1980 | 26 | BUF | FB | 16 | 16 | 153 | 559 | 3 | 34 | 3.7 | 34.9 | 4 |
| 81 | O.J. Simpson | 1977 | 30 | BUF | RB | 7 | 7 | 126 | 557 | 0 | 39 | 4.4 | 79.6 | 2 |
| 82 | Jim Braxton | 1974 | 25 | BUF | FB | 12 | 11 | 146 | 543 | 4 | 21 | 3.7 | 45.3 | 5 |
| 83 | Wray Carlton | 1960 | 23 | BUF | FB | 14 | 14 | 137 | 533 | 7 | 54 | 3.9 | 38.1 | 7 |
| 84 | Larry Kinnebrew | 1989 | 30 | BUF | FB | 15 | 10 | 131 | 533 | 6 | 25 | 4.1 | 35.5 | 3 |
| 85 | Josh Allen* | 2024 | 28 | BUF | QB | 17 | 17 | 102 | 531 | 12 | 30 | 5.2 | 31.2 | 5 |
| 86 | Wray Carlton | 1962 | 25 | BUF | HB | 11 | 11 | 94 | 530 | 2 | 51 | 5.6 | 48.2 | 5 |
| 87 | Max Anderson | 1968 | 23 | BUF | RB | 14 | 12 | 147 | 525 | 2 | 45 | 3.6 | 37.5 | 3 |
| 88 | Fred Jackson | 2014 | 33 | BUF | RB | 14 | 9 | 141 | 525 | 2 | 38 | 3.7 | 37.5 | 5 |
| 89 | Josh Allen | 2023 | 27 | BUF | QB | 17 | 17 | 111 | 524 | 15 | 23 | 4.7 | 30.8 | 7 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 90 | Karlos Williams | 2015 | 22 | BUF | RB | 11 | 3 | 93 | 517 | 7 | 41 | 5.6 | 47.0 | 2 |
| 91 | LeSean McCoy | 2018 | 30 | BUF | RB | 14 | 13 | 161 | 514 | 3 | 28 | 3.2 | 36.7 | 0 |
| 92 | Josh Allen | 2019 | 23 | BUF | QB | 16 | 16 | 109 | 510 | 9 | 36 | 4.7 | 31.9 | 14 |
| 93 | James Cook | 2022 | 23 | BUF | RB | 16 | 0 | 89 | 507 | 2 | 33 | 5.7 | 31.7 | 1 |
| 94 | Art Baker | 1961 | 24 | BUF | FB | 14 | 9 | 152 | 498 | 3 | 35 | 3.3 | 35.6 | 7 |
| 95 | Roland Hooks | 1977 | 24 | BUF | RB | 14 | 7 | 128 | 497 | 0 | 66 | 3.9 | 35.5 | 8 |
| 96 | Jim Braxton | 1973 | 24 | BUF | RB | 6 | 4 | 108 | 494 | 4 | 36 | 4.6 | 82.3 | 2 |
| 97 | O.J. Simpson | 1970 | 23 | BUF | RB | 8 | 8 | 120 | 488 | 5 | 56 | 4.1 | 61.0 | 6 |
| 98 | Ronnie Harmon | 1987 | 23 | BUF | RB | 12 | 10 | 116 | 485 | 2 | 21 | 4.2 | 40.4 | 2 |
| 99 | Terry Miller | 1979 | 23 | BUF | RB | 16 | 16 | 139 | 484 | 1 | 75 | 3.5 | 30.3 | 2 |
| 100 | Zack Moss | 2020 | 23 | BUF | RB | 13 | 0 | 112 | 481 | 4 | 31 | 4.3 | 37.0 | 0 |
| 101 | Doug Flutie | 1999 | 37 | BUF | QB | 15 | 15 | 88 | 476 | 1 | 24 | 5.4 | 31.7 | 6 |
| 102 | Jeff Kinney | 1976 | 27 | BUF | FB | 12 | 8 | 116 | 475 | 1 | 22 | 4.1 | 39.6 | 3 |
| 103 | Wray Carlton | 1967 | 30 | BUF | FB | 12 | 10 | 107 | 467 | 3 | 21 | 4.4 | 38.9 | 3 |
| 104 | Jim Braxton | 1972 | 23 | BUF | FB | 14 | 13 | 116 | 453 | 5 | 21 | 3.9 | 32.4 | 2 |
| 105 | Marshawn Lynch | 2009 | 23 | BUF | RB | 13 | 6 | 120 | 450 | 2 | 47 | 3.8 | 34.6 | 3 |
| 106 | Ray Davis | 2024 | 25 | BUF | RB | 17 | 0 | 113 | 442 | 3 | 23 | 3.9 | 26.0 | 0 |
| 107 | Robb Riddick | 1988 | 31 | BUF | RB | 15 | 0 | 111 | 438 | 12 | 21 | 3.9 | 29.2 | 3 |
| 108 | Fred Jackson | 2012 | 31 | BUF | RB | 10 | 8 | 115 | 437 | 3 | 15 | 3.8 | 43.7 | 5 |
| 109 | Anthony Dixon | 2014 | 27 | BUF | RB | 16 | 0 | 105 | 432 | 2 | 47 | 4.1 | 27.0 | 1 |
| 110 | Tyrod Taylor | 2017 | 28 | BUF | QB | 15 | 14 | 84 | 427 | 4 | 32 | 5.1 | 28.5 | 4 |
| 111 | Josh Allen* | 2020 | 24 | BUF | QB | 16 | 16 | 102 | 421 | 8 | 24 | 4.1 | 26.3 | 9 |
| 112 | Larry Watkins | 1973 | 27 | BUF | FB | 14 | 10 | 98 | 414 | 2 | 17 | 4.2 | 29.6 | 3 |
| 113 | Roosevelt Leaks | 1982 | 29 | BUF | FB | 9 | 9 | 97 | 405 | 5 | 17 | 4.2 | 45.0 | 2 |
| 114 | Joe Cribbs | 1985 | 27 | BUF | RB | 10 | 5 | 122 | 399 | 1 | 16 | 3.3 | 39.9 | 5 |
| 115 | Kenneth Davis | 1993 | 31 | BUF | RB | 16 | 0 | 109 | 391 | 6 | 19 | 3.6 | 24.4 | 3 |
| 116 | Chris Ivory | 2018 | 30 | BUF | RB | 13 | 1 | 115 | 385 | 1 | 21 | 3.3 | 29.6 | 1 |
| 117 | Thurman Thomas | 1998 | 32 | BUF | RB | 14 | 3 | 93 | 381 | 2 | 17 | 4.1 | 27.2 | 0 |
| 118 | Kenneth Davis | 1994 | 32 | BUF | RB | 16 | 1 | 91 | 381 | 2 | 60 | 4.2 | 23.8 | 3 |
| 119 | Anthony Thomas | 2006 | 29 | BUF | RB | 16 | 2 | 107 | 378 | 2 | 19 | 3.5 | 23.6 | 1 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 120 | Billy Joe* | 1965 | 25 | BUF | FB | 14 | 11 | 123 | 377 | 4 | 30 | 3.1 | 26.9 | 3 |
| 121 | Greg Bell | 1986 | 24 | BUF | RB | 6 | 6 | 90 | 377 | 4 | 42 | 4.2 | 62.8 | 2 |
| 122 | Jim Braxton | 1977 | 28 | BUF | FB | 14 | 14 | 113 | 372 | 1 | 12 | 3.3 | 26.6 | 7 |
| 123 | Willmer Fowler | 1960 | 23 | BUF | HB | 11 | 7 | 93 | 370 | 1 | 61 | 4.0 | 33.6 | 2 |
| 124 | Wayne Patrick | 1969 | 23 | BUF | RB | 14 | 10 | 83 | 361 | 3 | 72 | 4.3 | 25.8 | 6 |
| 125 | Roland Hooks | 1978 | 25 | BUF | RB | 16 | 0 | 76 | 358 | 2 | 66 | 4.7 | 22.4 | 2 |
| 126 | Roosevelt Leaks | 1981 | 28 | BUF | FB | 16 | 5 | 91 | 357 | 6 | 31 | 3.9 | 22.3 | 1 |
| 127 | Antowain Smith | 2000 | 28 | BUF | RB | 11 | 3 | 101 | 354 | 4 | 59 | 3.5 | 32.2 | 1 |
| 128 | Jamie Mueller | 1987 | 23 | BUF | FB | 12 | 6 | 82 | 354 | 2 | 20 | 4.3 | 29.5 | 5 |
| 129 | Zack Moss | 2021 | 24 | BUF | RB | 13 | 0 | 96 | 345 | 4 | 17 | 3.6 | 26.5 | 2 |
| 130 | Sammy Morris | 2000 | 23 | BUF | RB | 12 | 8 | 93 | 341 | 5 | 32 | 3.7 | 28.4 | 2 |
| 131 | Shawn Bryson | 2001 | 25 | BUF | RB | 15 | 3 | 80 | 341 | 2 | 68 | 4.3 | 22.7 | 0 |
| 132 | Wayne Patrick | 1971 | 25 | BUF | FB | 14 | 13 | 79 | 332 | 1 | 41 | 4.2 | 23.7 | 5 |
| 133 | Travis Henry | 2004 | 26 | BUF | RB | 10 | 5 | 94 | 326 | 0 | 19 | 3.5 | 32.6 | 0 |
| 134 | Roland Hooks | 1979 | 26 | BUF | RB | 16 | 0 | 89 | 320 | 6 | 32 | 3.6 | 20.0 | 4 |
| 135 | Wray Carlton | 1961 | 24 | BUF | FB | 14 | 8 | 101 | 311 | 4 | 27 | 3.1 | 22.2 | 5 |
| 136 | Rob Johnson | 2000 | 27 | BUF | QB | 12 | 11 | 42 | 307 | 1 | 23 | 7.3 | 25.6 | 4 |
| 137 | Bobby Smith | 1964 | 22 | BUF | HB | 14 | 3 | 62 | 306 | 4 | 37 | 4.9 | 21.9 | 2 |
| 138 | Kenneth Davis | 1990 | 28 | BUF | RB | 16 | 0 | 64 | 302 | 4 | 47 | 4.7 | 18.9 | 1 |
| 139 | Latavius Murray | 2023 | 33 | BUF | RB | 16 | 4 | 79 | 300 | 4 | 29 | 3.8 | 18.8 | 1 |
| 140 | C.J. Spiller | 2014 | 27 | BUF | RB | 9 | 5 | 78 | 300 | 0 | 53 | 3.8 | 33.3 | 3 |
| 141 | Fred Jackson | 2007 | 26 | BUF | RB | 8 | 1 | 58 | 300 | 0 | 27 | 5.2 | 37.5 | 0 |
| 142 | Jamie Mueller | 1988 | 24 | BUF | FB | 15 | 15 | 81 | 296 | 0 | 20 | 3.7 | 19.7 | 2 |
| 143 | Daryle Lamonica | 1964 | 23 | BUF | QB | 14 | 1 | 55 | 289 | 6 | 28 | 5.3 | 20.6 | 6 |
| 144 | C.J. Spiller | 2010 | 23 | BUF | RB | 14 | 1 | 74 | 283 | 0 | 20 | 3.8 | 20.2 | 5 |
| 145 | Ben Gregory | 1968 | 22 | BUF | RB | 6 | 6 | 52 | 283 | 1 | 67 | 5.4 | 47.2 | 2 |
| 146 | Carl Byrum | 1987 | 24 | BUF | FB | 13 | 8 | 66 | 280 | 0 | 30 | 4.2 | 21.5 | 4 |
| 147 | Joe Ferguson | 1977 | 27 | BUF | QB | 14 | 14 | 41 | 279 | 2 | 41 | 6.8 | 19.9 | 12 |
| 148 | Booker Moore | 1983 | 24 | BUF | FB | 15 | 11 | 60 | 275 | 0 | 21 | 4.6 | 18.3 | 1 |
| 149 | Ray Davis+ | 2025 | 26 | BUF | RB | 17 | 0 | 58 | 275 | 0 | 23 | 4.7 | 16.2 | 0 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 150 | Bob Cappadona | 1968 | 26 | BUF | RB | 14 | 7 | 73 | 272 | 1 | 33 | 3.7 | 19.4 | 3 |
| 151 | Ryan Fitzpatrick | 2010 | 28 | BUF | QB | 13 | 13 | 40 | 269 | 0 | 22 | 6.7 | 20.7 | 8 |
| 152 | Mike Gillislee | 2015 | 25 | BUF | RB | 5 | 1 | 47 | 267 | 3 | 60 | 5.7 | 53.4 | 1 |
| 153 | Wayne Patrick | 1970 | 24 | BUF | FB | 9 | 9 | 66 | 259 | 1 | 20 | 3.9 | 28.8 | 4 |
| 154 | Marcus Murphy | 2018 | 27 | BUF | RB | 11 | 1 | 52 | 250 | 0 | 30 | 4.8 | 22.7 | 1 |
| 155 | Roland Hooks | 1981 | 28 | BUF | RB | 16 | 1 | 51 | 250 | 3 | 19 | 4.9 | 15.6 | 1 |
| 156 | Doug Flutie* | 1998 | 36 | BUF | QB | 13 | 10 | 48 | 248 | 1 | 23 | 5.2 | 19.1 | 3 |
| 157 | Mike Tolbert | 2017 | 32 | BUF | RB | 12 | 0 | 66 | 247 | 1 | 25 | 3.7 | 20.6 | 2 |
| 158 | Rob Johnson | 2001 | 28 | BUF | QB | 8 | 8 | 36 | 241 | 1 | 23 | 6.7 | 30.1 | 6 |
| 159 | Jack Kemp* | 1963 | 28 | BUF | QB | 14 | 12 | 50 | 239 | 8 | 26 | 4.8 | 17.1 | 10 |
| 160 | Roger Kochman | 1963 | 22 | BUF | HB | 5 | 4 | 47 | 232 | 0 | 48 | 4.9 | 46.4 | 0 |
| 161 | Bruce Mathison | 1985 | 26 | BUF | QB | 10 | 7 | 27 | 231 | 1 | 22 | 8.6 | 23.1 | 8 |
| 162 | Gary Marangi | 1976 | 24 | BUF | QB | 11 | 7 | 39 | 230 | 2 | 21 | 5.9 | 20.9 | 12 |
| 163 | Curtis Brown | 1981 | 27 | BUF | FB | 14 | 8 | 62 | 226 | 0 | 13 | 3.6 | 16.1 | 4 |
| 164 | Dennis Johnson | 1978 | 22 | BUF | FB | 16 | 1 | 55 | 222 | 2 | 30 | 4.0 | 13.9 | 2 |
| 165 | Robb Riddick | 1987 | 30 | BUF | RB | 6 | 1 | 59 | 221 | 5 | 25 | 3.7 | 36.8 | 2 |
| 166 | Roosevelt Leaks | 1980 | 27 | BUF | RB | 16 | 0 | 67 | 219 | 2 | 15 | 3.3 | 13.7 | 1 |
| 167 | Ryan Fitzpatrick | 2011 | 29 | BUF | QB | 16 | 16 | 56 | 215 | 0 | 18 | 3.8 | 13.4 | 7 |
| 168 | Ty Johnson | 2024 | 27 | BUF | RB | 17 | 1 | 41 | 213 | 1 | 19 | 5.2 | 12.5 | 0 |
| 169 | Ronnie Harmon | 1988 | 24 | BUF | RB | 16 | 1 | 57 | 212 | 1 | 32 | 3.7 | 13.3 | 2 |
| 170 | Dennis Shaw | 1970 | 23 | BUF | QB | 14 | 12 | 39 | 210 | 0 | 20 | 5.4 | 15.0 | 10 |
| 171 | Jamie Mueller | 1990 | 26 | BUF | FB | 16 | 8 | 59 | 207 | 2 | 20 | 3.5 | 12.9 | 1 |
| 172 | Ty Johnson | 2025 | 28 | BUF | RB | 17 | 0 | 50 | 200 | 3 | 23 | 4.0 | 11.8 | 1 |
| 173 | Jim Kelly | 1986 | 26 | BUF | QB | 16 | 16 | 41 | 199 | 0 | 20 | 4.9 | 12.4 | 7 |
| 174 | Ryan Fitzpatrick | 2012 | 30 | BUF | QB | 16 | 16 | 48 | 197 | 1 | 20 | 4.1 | 12.3 | 8 |
| 175 | Bill Enyart | 1970 | 23 | BUF | RB | 14 | 5 | 58 | 196 | 0 | 17 | 3.4 | 14.0 | 2 |
| 176 | Jonathan Linton | 1998 | 24 | BUF | RB | 14 | 0 | 45 | 195 | 1 | 20 | 4.3 | 13.9 | 0 |
| 177 | Tashard Choice | 2012 | 28 | BUF | RB | 12 | 0 | 47 | 193 | 1 | 22 | 4.1 | 16.1 | 0 |
| 178 | Fred Brown | 1961 | 23 | BUF | LHB | 5 | 5 | 53 | 192 | 1 | 13 | 3.6 | 38.4 | 1 |
| 179 | Joe Auer | 1964 | 23 | BUF | LHB | 12 | 7 | 63 | 191 | 2 | 21 | 3.0 | 15.9 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 180 | Bill Enyart | 1969 | 22 | BUF | RB | 14 | 4 | 47 | 191 | 1 | 26 | 4.1 | 13.6 | 2 |
| 181 | Curtis Brown | 1982 | 28 | BUF | RB | 9 | 3 | 41 | 187 | 0 | 19 | 4.6 | 20.8 | 1 |
| 182 | EJ Manuel | 2013 | 23 | BUF | QB | 10 | 10 | 53 | 186 | 2 | 19 | 3.5 | 18.6 | 6 |
| 183 | Ricky Porter | 1987 | 27 | BUF | RB | 9 | 0 | 47 | 177 | 0 | 13 | 3.8 | 19.7 | 0 |
| 184 | Speedy Neal | 1984 | 22 | BUF | RB | 12 | 1 | 49 | 175 | 1 | 10 | 3.6 | 14.6 | 0 |
| 185 | Elbert Dubenion | 1961 | 28 | BUF | FL | 14 | 14 | 17 | 173 | 2 | 72 | 10.2 | 12.4 | 1 |
| 186 | Ronnie Harmon | 1986 | 22 | BUF | RB | 14 | 2 | 54 | 172 | 0 | 38 | 3.2 | 12.3 | 2 |
| 187 | Larry Watkins | 1974 | 28 | BUF | RB | 10 | 2 | 41 | 170 | 2 | 13 | 4.1 | 17.0 | 0 |
| 188 | Shaud Williams | 2004 | 24 | BUF | RB | 4 | 0 | 42 | 167 | 2 | 27 | 4.0 | 41.8 | 1 |
| 189 | Carwell Gardner | 1992 | 26 | BUF | FB | 16 | 7 | 40 | 166 | 2 | 19 | 4.2 | 10.4 | 0 |
| 190 | Marshawn Lynch | 2010 | 24 | BUF | RB | 4 | 3 | 37 | 164 | 0 | 17 | 4.4 | 41.0 | 1 |
| 191 | Lloyd Pate | 1970 | 24 | BUF | RB | 9 | 4 | 46 | 162 | 1 | 18 | 3.5 | 18.0 | 3 |
| 192 | Shaud Williams | 2005 | 25 | BUF | RB | 16 | 0 | 45 | 161 | 0 | 28 | 3.6 | 10.1 | 0 |
| 193 | Doug Flutie | 2000 | 38 | BUF | QB | 11 | 5 | 36 | 161 | 1 | 32 | 4.5 | 14.6 | 5 |
| 194 | Larry Centers* | 2001 | 33 | BUF | FB | 16 | 13 | 34 | 160 | 2 | 50 | 4.7 | 10.0 | 2 |
| 195 | Roosevelt Leaks | 1983 | 30 | BUF | RB | 12 | 4 | 58 | 157 | 1 | 12 | 2.7 | 13.1 | 0 |
| 196 | Carl Byrum | 1986 | 23 | BUF | RB | 13 | 3 | 38 | 156 | 0 | 18 | 4.1 | 12.0 | 0 |
| 197 | Jim Kelly* | 1988 | 28 | BUF | QB | 16 | 16 | 35 | 154 | 0 | 20 | 4.4 | 9.6 | 5 |
| 198 | J.P. Losman | 2005 | 24 | BUF | QB | 9 | 8 | 31 | 154 | 0 | 30 | 5.0 | 17.1 | 7 |
| 199 | Thurman Thomas | 1999 | 33 | BUF | RB | 5 | 3 | 36 | 152 | 0 | 31 | 4.2 | 30.4 | 0 |
| 200 | Kenneth Davis | 1989 | 27 | BUF | RB | 16 | 0 | 29 | 149 | 1 | 21 | 5.1 | 9.3 | 2 |
| 201 | Allen Smith | 1966 | 24 | BUF | RB | 14 | 0 | 31 | 148 | 0 | 20 | 4.8 | 10.6 | 0 |
| 202 | Joe Ferguson | 1973 | 23 | BUF | QB | 14 | 14 | 48 | 147 | 2 | 24 | 3.1 | 10.5 | 7 |
| 203 | Carwell Gardner | 1991 | 25 | BUF | FB | 16 | 5 | 42 | 146 | 4 | 18 | 3.5 | 9.1 | 4 |
| 204 | Ed Rutkowski | 1963 | 22 | BUF | HB | 14 | 7 | 48 | 144 | 0 | 45 | 3.0 | 10.3 | 1 |
| 205 | M.C. Reynolds | 1961 | 26 | BUF | QB | 12 | 3 | 30 | 142 | 4 | 20 | 4.7 | 11.8 | 1 |
| 206 | Ryan Fitzpatrick | 2009 | 27 | BUF | QB | 10 | 8 | 31 | 141 | 1 | 31 | 4.5 | 14.1 | 3 |
| 207 | J.P. Losman | 2006 | 25 | BUF | QB | 16 | 16 | 38 | 140 | 1 | 15 | 3.7 | 8.8 | 13 |
| 208 | Richie Lucas | 1960 | 22 | BUF | LHB | 14 | 7 | 38 | 138 | 2 | 16 | 3.6 | 9.9 | 2 |
| 209 | Dennis Shaw | 1972 | 25 | BUF | QB | 14 | 13 | 35 | 138 | 0 | 16 | 3.9 | 9.9 | 6 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 210 | Lawrence McCutcheon | 1981 | 31 | BUF | RB | 6 | 3 | 34 | 138 | 0 | 12 | 4.1 | 23.0 | 1 |
| 211 | Bobby Smith* | 1965 | 23 | BUF | HB | 14 | 3 | 43 | 137 | 1 | 13 | 3.2 | 9.8 | 2 |
| 212 | Jim Kelly | 1989 | 29 | BUF | QB | 13 | 13 | 29 | 137 | 2 | 19 | 4.7 | 10.5 | 6 |
| 213 | Andre Reed* | 1991 | 27 | BUF | WR | 16 | 16 | 12 | 136 | 0 | 46 | 11.3 | 8.5 | 1 |
| 214 | Carwell Gardner | 1994 | 28 | BUF | FB | 16 | 7 | 41 | 135 | 4 | 13 | 3.3 | 8.4 | 1 |
| 215 | Dewey Bohling | 1961 | 23 | BUF | LHB | 7 | 6 | 42 | 134 | 2 | 18 | 3.2 | 19.1 | 1 |
| 216 | Jim Kelly* | 1987 | 27 | BUF | QB | 12 | 12 | 29 | 133 | 0 | 24 | 4.6 | 11.1 | 6 |
| 217 | Ty Johnson | 2023 | 26 | BUF | RB | 10 | 0 | 30 | 132 | 0 | 13 | 4.4 | 13.2 | 1 |
| 218 | Jack Kemp* | 1966 | 31 | BUF | QB | 14 | 14 | 40 | 130 | 5 | 26 | 3.3 | 9.3 | 7 |
| 219 | Wayne Patrick | 1972 | 26 | BUF | RB | 13 | 1 | 35 | 130 | 0 | 9 | 3.7 | 10.0 | 3 |
| 220 | Mike Collier | 1979 | 26 | BUF | RB | 16 | 1 | 34 | 130 | 2 | 22 | 3.8 | 8.1 | 3 |
| 221 | Bryce Brown | 2014 | 23 | BUF | RB | 7 | 2 | 36 | 126 | 0 | 14 | 3.5 | 18.0 | 1 |
| 222 | Tashard Choice | 2013 | 29 | BUF | RB | 12 | 0 | 35 | 126 | 0 | 20 | 3.6 | 10.5 | 0 |
| 223 | Wray Carlton | 1963 | 26 | BUF | HB | 4 | 2 | 29 | 125 | 0 | 19 | 4.3 | 31.3 | 1 |
| 224 | Matt Breida | 2021 | 26 | BUF | RB | 9 | 0 | 26 | 125 | 1 | 28 | 4.8 | 13.9 | 1 |
| 225 | Jack Kemp* | 1964 | 29 | BUF | QB | 14 | 13 | 37 | 124 | 5 | 14 | 3.4 | 8.9 | 7 |
| 226 | Jack Kemp* | 1969 | 34 | BUF | QB | 14 | 11 | 37 | 124 | 0 | 13 | 3.4 | 8.9 | 8 |
| 227 | Rob Johnson | 1998 | 25 | BUF | QB | 8 | 6 | 24 | 123 | 1 | 32 | 5.1 | 15.4 | 2 |
| 228 | Jack Spikes | 1966 | 29 | BUF | HB | 14 | 1 | 28 | 119 | 3 | 36 | 4.3 | 8.5 | 1 |
| 229 | Roland Hooks | 1980 | 27 | BUF | RB | 16 | 0 | 25 | 118 | 1 | 25 | 4.7 | 7.4 | 3 |
| 230 | Trent Edwards | 2008 | 25 | BUF | QB | 14 | 14 | 36 | 117 | 3 | 15 | 3.3 | 8.4 | 9 |
| 231 | Mike Collier | 1977 | 24 | BUF | RB | 6 | 0 | 31 | 116 | 0 | 15 | 3.7 | 19.3 | 1 |
| 232 | Roland Hooks | 1976 | 23 | BUF | RB | 14 | 1 | 25 | 116 | 0 | 24 | 4.6 | 8.3 | 4 |
| 233 | Brad Smith | 2012 | 29 | BUF | WR/QB | 15 | 2 | 14 | 116 | 1 | 35 | 8.3 | 7.7 | 1 |
| 234 | Wray Carlton | 1964 | 27 | BUF | HB | 4 | 4 | 39 | 114 | 1 | 11 | 2.9 | 28.5 | 2 |
| 235 | Joe Burns | 2003 | 24 | BUF | RB | 16 | 1 | 39 | 113 | 0 | 12 | 2.9 | 7.1 | 1 |
| 236 | Greg Jones | 1970 | 22 | BUF | RB | 10 | 2 | 31 | 113 | 1 | 17 | 3.6 | 11.3 | 0 |
| 237 | Jonathan Linton | 2000 | 26 | BUF | RB | 14 | 2 | 38 | 112 | 0 | 12 | 2.9 | 8.0 | 3 |
| 238 | Joe Ferguson | 1974 | 24 | BUF | QB | 14 | 14 | 54 | 111 | 2 | 15 | 2.1 | 7.9 | 14 |
| 239 | J.P. Losman | 2007 | 26 | BUF | QB | 8 | 7 | 20 | 110 | 0 | 17 | 5.5 | 13.8 | 5 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 240 | Joe Kulbacki | 1960 | 22 | BUF | HB | 14 | 1 | 41 | 108 | 1 | 17 | 2.6 | 7.7 | 4 |
| 241 | Darick Holmes | 1997 | 26 | BUF | RB | 13 | 0 | 22 | 106 | 2 | 19 | 4.8 | 8.2 | 1 |
| 242 | Trent Edwards | 2009 | 26 | BUF | QB | 8 | 7 | 14 | 106 | 0 | 20 | 7.6 | 13.3 | 1 |
| 243 | Ricky Moore | 1986 | 23 | BUF | FB | 11 | 8 | 33 | 104 | 1 | 14 | 3.2 | 9.5 | 2 |
| 244 | Gary McDermott | 1968 | 22 | BUF | RB | 14 | 3 | 47 | 102 | 3 | 17 | 2.2 | 7.3 | 2 |
| 245 | Jim Kelly | 1993 | 33 | BUF | QB | 16 | 16 | 36 | 102 | 0 | 17 | 2.8 | 6.4 | 7 |
| 246 | Joe Ferguson | 1984 | 34 | BUF | QB | 12 | 11 | 19 | 102 | 0 | 20 | 5.4 | 8.5 | 8 |
| 247 | Bob Brodhead | 1960 | 24 | BUF | QB | 4 | 1 | 15 | 100 | 0 | 19 | 6.7 | 25.0 | 0 |
| 248 | Ronnie Harmon | 1989 | 25 | BUF | RB | 15 | 2 | 17 | 99 | 0 | 24 | 5.8 | 6.6 | 2 |
| 249 | Peerless Price | 2001 | 25 | BUF | WR | 16 | 16 | 6 | 97 | 0 | 31 | 16.2 | 6.1 | 2 |
| 250 | Bobby Burnett | 1967 | 24 | BUF | RB | 8 | 3 | 45 | 96 | 0 | 18 | 2.1 | 12.0 | 4 |
| 251 | Ed Rutkowski | 1968 | 27 | BUF | QB | 13 | 3 | 20 | 96 | 1 | 33 | 4.8 | 7.4 | 2 |
| 252 | Dwayne Wright | 2007 | 24 | BUF | RB | 15 | 0 | 29 | 94 | 0 | 15 | 3.2 | 6.3 | 1 |
| 253 | Jonathan Williams | 2016 | 22 | BUF | RB | 11 | 0 | 27 | 94 | 1 | 20 | 3.5 | 8.5 | 2 |
| 254 | Damien Harris | 2023 | 26 | BUF | RB | 6 | 0 | 23 | 94 | 1 | 11 | 4.1 | 15.7 | 0 |
| 255 | Elbert Dubenion | 1960 | 27 | BUF | FL | 14 | 14 | 16 | 94 | 1 | 66 | 5.9 | 6.7 | 3 |
| 256 | Travaris Cadet | 2017 | 28 | BUF | RB | 6 | 0 | 22 | 93 | 0 | 12 | 4.2 | 15.5 | 0 |
| 257 | Carl Byrum | 1988 | 25 | BUF | RB | 15 | 1 | 28 | 91 | 0 | 11 | 3.3 | 6.1 | 1 |
| 258 | Zack Moss | 2022 | 25 | BUF | RB | 5 | 0 | 17 | 91 | 0 | 43 | 5.4 | 18.2 | 1 |
| 259 | Anthony Thomas | 2007 | 30 | BUF | RB | 10 | 2 | 36 | 89 | 0 | 9 | 2.5 | 8.9 | 0 |
| 260 | Don Calhoun | 1974 | 22 | BUF | RB | 14 | 1 | 21 | 88 | 0 | 15 | 4.2 | 6.3 | 0 |
| 261 | Joe Ferguson | 1983 | 33 | BUF | QB | 16 | 16 | 20 | 88 | 0 | 19 | 4.4 | 5.5 | 3 |
| 262 | Brad Smith | 2011 | 28 | BUF | WR | 15 | 5 | 20 | 87 | 1 | 18 | 4.4 | 5.8 | 0 |
| 263 | Andre Reed* | 1994 | 30 | BUF | WR | 16 | 16 | 10 | 87 | 0 | 20 | 8.7 | 5.4 | 3 |
| 264 | Billy Atkins*+ | 1961 | 27 | BUF | FS | 14 | 14 | 2 | 87 | 1 | 56 | 43.5 | 6.2 | 0 |
| 265 | Lee Evans | 2004 | 23 | BUF | WR | 16 | 11 | 5 | 85 | 0 | 48 | 17.0 | 5.3 | 1 |
| 266 | Keith Lincoln | 1968 | 29 | BUF | HB | 4 | 0 | 26 | 84 | 0 | 24 | 3.2 | 21.0 | 1 |
| 267 | Booker Moore | 1984 | 25 | BUF | FB | 15 | 15 | 24 | 84 | 0 | 21 | 3.5 | 5.6 | 4 |
| 268 | Jim Braxton | 1971 | 22 | BUF | RB | 13 | 0 | 21 | 84 | 0 | 14 | 4.0 | 6.5 | 2 |
| 269 | Joe Ferguson | 1975 | 25 | BUF | QB | 14 | 14 | 23 | 82 | 1 | 17 | 3.6 | 5.9 | 4 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 270 | Don Smith | 1990 | 27 | BUF | RB | 16 | 2 | 20 | 82 | 2 | 13 | 4.1 | 5.1 | 1 |
| 271 | Dennis Shaw | 1971 | 24 | BUF | QB | 13 | 12 | 14 | 82 | 0 | 12 | 5.9 | 6.3 | 4 |
| 272 | Joe Ferguson | 1976 | 26 | BUF | QB | 7 | 7 | 18 | 81 | 0 | 19 | 4.5 | 11.6 | 2 |
| 273 | Don Calhoun | 1975 | 23 | BUF | RB | 6 | 0 | 19 | 80 | 0 | 11 | 4.2 | 13.3 | 1 |
| 274 | Matt Kofler | 1984 | 25 | BUF | QB | 16 | 0 | 10 | 80 | 0 | 19 | 8.0 | 5.0 | 1 |
| 275 | Keith Ford | 2018 | 24 | BUF | RB | 2 | 1 | 21 | 79 | 0 | 11 | 3.8 | 39.5 | 0 |
| 276 | Gary Marangi | 1975 | 23 | BUF | QB | 5 | 0 | 7 | 78 | 0 | 30 | 11.1 | 15.6 | 0 |
| 277 | Warren Rabb | 1962 | 25 | BUF | QB | 14 | 8 | 37 | 77 | 3 | 14 | 2.1 | 5.5 | 6 |
| 278 | Todd Collins | 1997 | 26 | BUF | QB | 14 | 13 | 30 | 77 | 0 | 11 | 2.6 | 5.5 | 10 |
| 279 | Jim Kelly | 1994 | 34 | BUF | QB | 14 | 14 | 25 | 77 | 1 | 18 | 3.1 | 5.5 | 11 |
| 280 | Carwell Gardner | 1995 | 29 | BUF | FB | 15 | 4 | 20 | 77 | 0 | 17 | 3.9 | 5.1 | 0 |
| 281 | Joe Ferguson | 1978 | 28 | BUF | QB | 16 | 16 | 27 | 76 | 0 | 12 | 2.8 | 4.8 | 5 |
| 282 | Max Anderson | 1969 | 24 | BUF | RB | 11 | 1 | 13 | 74 | 1 | 16 | 5.7 | 6.7 | 1 |
| 283 | Steve Tasker* | 1995 | 33 | BUF | WR | 13 | 3 | 8 | 74 | 0 | 17 | 9.3 | 5.7 | 0 |
| 284 | Jim Braxton | 1978 | 29 | BUF | RB | 6 | 5 | 30 | 73 | 0 | 5 | 2.4 | 12.2 | 1 |
| 285 | Joe Burns | 2004 | 25 | BUF | RB | 16 | 0 | 20 | 73 | 0 | 21 | 3.7 | 4.6 | 0 |
| 286 | Sammy Morris | 2001 | 24 | BUF | RB | 16 | 1 | 20 | 72 | 0 | 10 | 3.6 | 4.5 | 1 |
| 287 | Tashard Choice | 2011 | 27 | BUF | RB | 6 | 0 | 23 | 70 | 1 | 12 | 3.0 | 11.7 | 1 |
| 288 | Sammy Morris | 2003 | 26 | BUF | RB | 9 | 0 | 19 | 70 | 1 | 12 | 3.7 | 7.8 | 0 |
| 289 | J.P. Losman | 2008 | 27 | BUF | QB | 5 | 2 | 12 | 70 | 2 | 17 | 5.8 | 14.0 | 8 |
| 290 | T.J. Yeldon | 2020 | 27 | BUF | RB | 3 | 0 | 10 | 70 | 0 | 34 | 7.0 | 23.3 | 1 |
| 291 | Billy Masters | 1968 | 24 | BUF | TE | 14 | 1 | 6 | 70 | 0 | 35 | 11.7 | 5.0 | 0 |
| 292 | Joe Ferguson | 1979 | 29 | BUF | QB | 16 | 16 | 22 | 68 | 1 | 15 | 3.1 | 4.3 | 5 |
| 293 | Drew Bledsoe* | 2002 | 30 | BUF | QB | 16 | 16 | 27 | 67 | 2 | 11 | 2.5 | 4.2 | 11 |
| 294 | Jim Kelly | 1996 | 36 | BUF | QB | 13 | 13 | 19 | 66 | 2 | 22 | 3.5 | 5.1 | 9 |
| 295 | Isaiah McKenzie | 2018 | 23 | BUF | WR | 7 | 1 | 10 | 66 | 2 | 15 | 6.6 | 9.4 | 2 |
| 296 | Joe Ferguson | 1980 | 30 | BUF | QB | 16 | 16 | 31 | 65 | 0 | 15 | 2.1 | 4.1 | 9 |
| 297 | Vic Washington | 1976 | 30 | BUF | RB | 2 | 1 | 22 | 65 | 0 | 10 | 3.0 | 32.5 | 0 |
| 298 | Andre Reed* | 1992 | 28 | BUF | WR | 16 | 16 | 8 | 65 | 0 | 24 | 8.1 | 4.1 | 4 |
| 299 | EJ Manuel | 2015 | 25 | BUF | QB | 7 | 2 | 17 | 64 | 1 | 16 | 3.8 | 9.1 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 300 | Andre Reed* | 1988 | 24 | BUF | WR | 15 | 14 | 6 | 64 | 0 | 36 | 10.7 | 4.3 | 1 |
| 301 | Jim Kelly* | 1990 | 30 | BUF | QB | 14 | 14 | 22 | 63 | 0 | 15 | 2.9 | 4.5 | 4 |
| 302 | T.J. Yeldon | 2019 | 26 | BUF | RB | 6 | 0 | 17 | 63 | 0 | 12 | 3.7 | 10.5 | 1 |
| 303 | Antonio Williams | 2020 | 23 | BUF | RB | 1 | 0 | 12 | 63 | 2 | 18 | 5.3 | 63.0 | 0 |
| 304 | Carl Smith | 1960 | 28 | BUF | FB | 14 | 0 | 19 | 61 | 0 | 13 | 3.2 | 4.4 | 0 |
| 305 | Donnie Stone | 1965 | 28 | BUF | FB | 14 | 0 | 19 | 61 | 0 | 14 | 3.2 | 4.4 | 1 |
| 306 | Rob Johnson | 1999 | 26 | BUF | QB | 2 | 1 | 8 | 61 | 0 | 25 | 7.6 | 30.5 | 0 |
| 307 | Greg Bell | 1987 | 25 | BUF | RB | 2 | 2 | 14 | 60 | 0 | 11 | 4.3 | 30.0 | 0 |
| 308 | Glenn Bass | 1963 | 24 | BUF | WR | 9 | 0 | 14 | 59 | 0 | 9 | 4.2 | 6.6 | 0 |
| 309 | Eric Moulds | 1997 | 24 | BUF | WR | 16 | 8 | 4 | 59 | 0 | 29 | 14.8 | 3.7 | 3 |
| 310 | Jack Kemp | 1967 | 32 | BUF | QB | 14 | 11 | 36 | 58 | 2 | 14 | 1.6 | 4.1 | 14 |
| 311 | Charlie Bivins | 1967 | 29 | BUF | HB | 9 | 1 | 15 | 58 | 0 | 43 | 3.9 | 6.4 | 0 |
| 312 | Randy Jackson | 1972 | 24 | BUF | RB | 5 | 0 | 17 | 57 | 0 | 15 | 3.4 | 11.4 | 0 |
| 313 | Al Dorow | 1962 | 33 | BUF | QB | 4 | 4 | 15 | 57 | 0 | 15 | 3.8 | 14.3 | 2 |
| 314 | Eddie Ray | 1976 | 29 | BUF | RB | 7 | 3 | 24 | 56 | 0 | 7 | 2.3 | 8.0 | 5 |
| 315 | Carwell Gardner | 1993 | 27 | BUF | FB | 13 | 2 | 20 | 56 | 0 | 8 | 2.8 | 4.3 | 1 |
| 316 | Yonel Jourdain | 1994 | 23 | BUF | RB | 9 | 0 | 17 | 56 | 0 | 16 | 3.3 | 6.2 | 1 |
| 317 | Jack Kemp* | 1962 | 27 | BUF | QB | 4 | 2 | 12 | 56 | 1 | 28 | 4.7 | 14.0 | 1 |
| 318 | Larry Centers | 2002 | 34 | BUF | FB | 16 | 7 | 11 | 56 | 2 | 13 | 5.1 | 3.5 | 0 |
| 319 | Isaiah McKenzie | 2022 | 27 | BUF | WR | 15 | 8 | 9 | 55 | 1 | 18 | 6.1 | 3.7 | 0 |
| 320 | Joe Webb | 2017 | 31 | BUF | WR | 16 | 0 | 8 | 54 | 0 | 22 | 6.8 | 3.4 | 0 |
| 321 | Terrell Owens | 2009 | 36 | BUF | WR | 16 | 16 | 6 | 54 | 1 | 29 | 9.0 | 3.4 | 1 |
| 322 | Jim Kelly* | 1992 | 32 | BUF | QB | 16 | 16 | 31 | 53 | 1 | 10 | 1.7 | 3.3 | 8 |
| 323 | Greg Jones | 1971 | 23 | BUF | RB | 14 | 1 | 16 | 53 | 0 | 11 | 3.3 | 3.8 | 1 |
| 324 | Thaddeus Lewis | 2013 | 26 | BUF | QB | 6 | 5 | 24 | 52 | 1 | 8 | 2.2 | 8.7 | 7 |
| 325 | EJ Manuel | 2014 | 24 | BUF | QB | 5 | 4 | 16 | 52 | 1 | 8 | 3.3 | 10.4 | 1 |
| 326 | Van Williams | 1984 | 25 | BUF | RB | 16 | 0 | 18 | 51 | 0 | 7 | 2.8 | 3.2 | 1 |
| 327 | Nathan Peterman | 2018 | 24 | BUF | QB | 4 | 2 | 10 | 50 | 1 | 24 | 5.0 | 12.5 | 0 |
| 328 | Jack Kemp*+ | 1965 | 30 | BUF | QB | 14 | 13 | 36 | 49 | 4 | 12 | 1.4 | 3.5 | 9 |
| 329 | Trent Edwards | 2007 | 24 | BUF | QB | 10 | 9 | 14 | 49 | 0 | 14 | 3.5 | 4.9 | 4 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 330 | Tim Tindale | 1996 | 25 | BUF | FB | 14 | 3 | 14 | 49 | 0 | 15 | 3.5 | 3.5 | 1 |
| 331 | Vic Washington | 1975 | 29 | BUF | DB | 13 | 4 | 9 | 49 | 0 | 9 | 5.4 | 3.8 | 1 |
| 332 | Isaiah McKenzie | 2019 | 24 | BUF | WR | 15 | 8 | 8 | 49 | 0 | 16 | 6.1 | 3.3 | 0 |
| 333 | Andre Reed | 1995 | 31 | BUF | WR | 6 | 6 | 7 | 48 | 0 | 14 | 6.9 | 8.0 | 2 |
| 334 | Brandon Tate | 2016 | 29 | BUF | WR | 15 | 1 | 3 | 48 | 0 | 30 | 16.0 | 3.2 | 0 |
| 335 | Warren Rabb | 1961 | 24 | BUF | QB | 9 | 2 | 13 | 47 | 0 | 19 | 3.6 | 5.2 | 5 |
| 336 | Isaiah McKenzie | 2021 | 26 | BUF | WR | 15 | 2 | 9 | 47 | 1 | 10 | 5.2 | 3.1 | 2 |
| 337 | Billy Atkins | 1960 | 26 | BUF | RCB | 14 | 14 | 2 | 47 | 0 | 36 | 23.5 | 3.4 | 1 |
| 338 | Joe Ferguson | 1982 | 32 | BUF | QB | 9 | 9 | 16 | 46 | 1 | 13 | 2.9 | 5.1 | 5 |
| 339 | Frank Summers | 2013 | 28 | BUF | RB | 15 | 9 | 12 | 46 | 1 | 16 | 3.8 | 3.1 | 0 |
| 340 | Kevin Williams | 1998 | 27 | BUF | WR | 16 | 0 | 5 | 46 | 0 | 28 | 9.2 | 2.9 | 3 |
| 341 | Jim Kelly*+ | 1991 | 31 | BUF | QB | 15 | 15 | 20 | 45 | 1 | 12 | 2.3 | 3.0 | 6 |
| 342 | Anthony Dixon | 2015 | 28 | BUF | RB | 16 | 1 | 21 | 44 | 1 | 6 | 2.1 | 2.8 | 0 |
| 343 | Jamie Mueller | 1989 | 25 | BUF | RB | 14 | 3 | 16 | 44 | 0 | 9 | 2.8 | 3.1 | 1 |
| 344 | Eric Moulds | 1996 | 23 | BUF | WR | 16 | 5 | 12 | 44 | 0 | 11 | 3.7 | 2.8 | 1 |
| 345 | Todd Collins | 1996 | 25 | BUF | QB | 7 | 3 | 21 | 43 | 0 | 10 | 2.0 | 6.1 | 3 |
| 346 | Johnny Shepherd | 1987 | 30 | BUF | RB | 2 | 1 | 12 | 42 | 0 | 19 | 3.5 | 21.0 | 0 |
| 347 | James Harris | 1971 | 24 | BUF | QB | 7 | 2 | 6 | 42 | 0 | 13 | 7.0 | 6.0 | 3 |
| 348 | Carwell Gardner | 1990 | 24 | BUF | FB | 7 | 0 | 15 | 41 | 0 | 14 | 2.7 | 5.9 | 0 |
| 349 | George Saimes | 1963 | 22 | BUF | FS | 14 | 12 | 12 | 41 | 0 | 7 | 3.4 | 2.9 | 0 |
| 350 | Marcus Murphy | 2017 | 26 | BUF | RB | 1 | 0 | 7 | 41 | 0 | 25 | 5.9 | 41.0 | 0 |
| 351 | Fred Ford | 1960 | 22 | BUF | HB | 3 | 1 | 18 | 40 | 0 | 7 | 2.2 | 13.3 | 0 |
| 352 | Leonard Fournette | 2023 | 28 | BUF | RB | 2 | 0 | 12 | 40 | 0 | 9 | 3.3 | 20.0 | 0 |
| 353 | Darnell Powell | 1976 | 22 | BUF | RB | 11 | 0 | 11 | 40 | 0 | 20 | 3.6 | 3.6 | 0 |
| 354 | Elbert Dubenion | 1962 | 29 | BUF | FL | 14 | 14 | 7 | 40 | 0 | 43 | 5.7 | 2.9 | 1 |
| 355 | Eddie Fuller | 1992 | 24 | BUF | RB | 8 | 0 | 6 | 39 | 0 | 15 | 6.5 | 4.9 | 0 |
| 356 | Charlie Brown | 1968 | 26 | BUF | DB | 8 | 0 | 3 | 39 | 0 | 27 | 13.0 | 4.9 | 1 |
| 357 | Quinn Early | 1996 | 31 | BUF | WR | 16 | 13 | 3 | 39 | 0 | 29 | 13.0 | 2.4 | 0 |
| 358 | Booker Moore | 1982 | 23 | BUF | RB | 5 | 0 | 16 | 38 | 0 | 9 | 2.4 | 7.6 | 2 |
| 359 | Johnny White | 2011 | 23 | BUF | RB | 12 | 0 | 12 | 38 | 0 | 13 | 3.2 | 3.2 | 0 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 360 | Lennox Gordon | 1999 | 21 | BUF | RB | 8 | 0 | 11 | 38 | 0 | 13 | 3.5 | 4.8 | 0 |
| 361 | Lee Evans | 2005 | 24 | BUF | WR | 16 | 15 | 4 | 38 | 0 | 39 | 9.5 | 2.4 | 0 |
| 362 | Josh Reed | 2003 | 23 | BUF | WR | 16 | 16 | 3 | 38 | 0 | 16 | 12.7 | 2.4 | 1 |
| 363 | Drew Bledsoe | 2004 | 32 | BUF | QB | 16 | 16 | 22 | 37 | 0 | 17 | 1.7 | 2.3 | 9 |
| 364 | Dan Herron | 2015 | 26 | BUF | RB | 4 | 0 | 11 | 37 | 0 | 8 | 3.4 | 9.3 | 1 |
| 365 | Nate Turner | 1993 | 24 | BUF | TE | 13 | 0 | 11 | 36 | 0 | 10 | 3.3 | 2.8 | 0 |
| 366 | Shawn Bryson | 2002 | 26 | BUF | RB | 6 | 0 | 13 | 35 | 0 | 10 | 2.7 | 5.8 | 1 |
| 367 | Terry Miller | 1980 | 24 | BUF | RB | 15 | 0 | 12 | 35 | 0 | 6 | 2.9 | 2.3 | 0 |
| 368 | Curtis Brown | 1977 | 23 | BUF | RB | 7 | 0 | 8 | 34 | 0 | 9 | 4.3 | 4.9 | 0 |
| 369 | Johnny White | 2012 | 24 | BUF | RB | 3 | 0 | 8 | 34 | 0 | 9 | 4.3 | 11.3 | 0 |
| 370 | Corey McIntyre | 2009 | 30 | BUF | FB | 15 | 4 | 5 | 34 | 0 | 25 | 6.8 | 2.3 | 0 |
| 371 | Alex Van Pelt | 2001 | 31 | BUF | QB | 12 | 8 | 12 | 33 | 0 | 15 | 2.8 | 2.8 | 5 |
| 372 | Alex Van Pelt | 1997 | 27 | BUF | QB | 6 | 3 | 11 | 33 | 1 | 9 | 3.0 | 5.5 | 3 |
| 373 | Sam Gash* | 1998 | 29 | BUF | FB | 16 | 13 | 11 | 32 | 0 | 11 | 2.9 | 2.0 | 0 |
| 374 | Peerless Price | 2000 | 24 | BUF | WR | 16 | 16 | 2 | 32 | 0 | 27 | 16.0 | 2.0 | 4 |
| 375 | Steve Tasker | 1996 | 34 | BUF | WR | 8 | 5 | 9 | 31 | 0 | 11 | 3.4 | 3.9 | 3 |
| 376 | Yonel Jourdain | 1995 | 24 | BUF | RB | 8 | 0 | 8 | 31 | 0 | 19 | 3.9 | 3.9 | 2 |
| 377 | Gary Hayman | 1974 | 23 | BUF | RB | 1 | 0 | 7 | 31 | 0 | 8 | 4.4 | 31.0 | 0 |
| 378 | Percy Harvin | 2015 | 27 | BUF | WR | 5 | 5 | 5 | 31 | 0 | 9 | 6.2 | 6.2 | 1 |
| 379 | Andre Reed* | 1989 | 25 | BUF | WR | 16 | 16 | 2 | 31 | 0 | 23 | 15.5 | 1.9 | 4 |
| 380 | Emmanuel Sanders | 2021 | 34 | BUF | WR | 14 | 13 | 2 | 31 | 0 | 24 | 15.5 | 2.2 | 0 |
| 381 | Gary Hayman | 1975 | 24 | BUF | RB | 14 | 0 | 10 | 30 | 0 | 7 | 3.0 | 2.1 | 3 |
| 382 | Daryle Lamonica* | 1965 | 24 | BUF | QB | 14 | 1 | 10 | 30 | 1 | 10 | 3.0 | 2.1 | 2 |
| 383 | Frank Reich | 1989 | 28 | BUF | QB | 7 | 3 | 9 | 30 | 0 | 9 | 3.3 | 4.3 | 2 |
| 384 | Kay Stephenson | 1968 | 24 | BUF | QB | 10 | 3 | 4 | 30 | 0 | 12 | 7.5 | 3.0 | 0 |
| 385 | Bill Brooks | 1993 | 29 | BUF | WR | 16 | 13 | 3 | 30 | 0 | 15 | 10.0 | 1.9 | 0 |
| 386 | Drew Bledsoe | 2003 | 31 | BUF | QB | 16 | 16 | 24 | 29 | 2 | 11 | 1.2 | 1.8 | 15 |
| 387 | Johnny Green | 1960 | 23 | BUF | QB | 10 | 6 | 21 | 29 | 2 | 11 | 1.4 | 2.9 | 9 |
| 388 | Joe Ferguson | 1981 | 31 | BUF | QB | 16 | 16 | 20 | 29 | 1 | 16 | 1.5 | 1.8 | 2 |
| 389 | Steve Powell | 1979 | 23 | BUF | RB | 15 | 0 | 10 | 29 | 0 | 9 | 2.9 | 1.9 | 0 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 390 | Dan Manucci | 1980 | 23 | BUF | QB | 2 | 0 | 3 | 29 | 0 | 17 | 9.7 | 14.5 | 0 |
| 391 | Robb Riddick | 1981 | 24 | BUF | RB | 10 | 0 | 3 | 29 | 0 | 12 | 9.7 | 2.9 | 1 |
| 392 | Robert Foster | 2019 | 25 | BUF | WR | 13 | 2 | 2 | 29 | 0 | 22 | 14.5 | 2.2 | 0 |
| 393 | Bruce King | 1987 | 24 | BUF | RB | 3 | 2 | 9 | 28 | 0 | 8 | 3.1 | 9.3 | 0 |
| 394 | Tony Hunter | 1983 | 23 | BUF | TE | 13 | 3 | 2 | 28 | 0 | 24 | 14.0 | 2.2 | 1 |
| 395 | Bob Chandler | 1972 | 23 | BUF | WR | 14 | 14 | 3 | 27 | 0 | 16 | 9.0 | 1.9 | 1 |
| 396 | Mitchell Brookins | 1984 | 24 | BUF | WR | 16 | 0 | 2 | 27 | 0 | 16 | 13.5 | 1.7 | 0 |
| 397 | Anthony Steels | 1985 | 26 | BUF | RB | 9 | 0 | 4 | 26 | 0 | 22 | 6.5 | 2.9 | 2 |
| 398 | Dan Darragh | 1970 | 24 | BUF | QB | 3 | 2 | 1 | 26 | 0 | 26 | 26.0 | 8.7 | 0 |
| 399 | James Harris | 1969 | 22 | BUF | QB | 4 | 1 | 10 | 25 | 0 | 9 | 2.5 | 6.3 | 3 |
| 400 | Leonard Williams | 1987 | 27 | BUF | RB | 2 | 0 | 9 | 25 | 0 | 9 | 2.8 | 12.5 | 0 |
| 401 | Matt Kofler | 1983 | 24 | BUF | QB | 16 | 0 | 4 | 25 | 0 | 11 | 6.3 | 1.6 | 0 |
| 402 | Preston Ridlehuber | 1969 | 26 | BUF | RB | 9 | 0 | 4 | 25 | 0 | 11 | 6.3 | 2.8 | 0 |
| 403 | Frank Reich | 1990 | 29 | BUF | QB | 16 | 2 | 15 | 24 | 0 | 9 | 1.6 | 1.5 | 1 |
| 404 | Mitchell Trubisky | 2021 | 27 | BUF | QB | 6 | 0 | 13 | 24 | 1 | 22 | 1.8 | 4.0 | 0 |
| 405 | Mike Pruitt | 1985 | 31 | BUF | RB | 4 | 2 | 7 | 24 | 0 | 7 | 3.4 | 6.0 | 0 |
| 406 | Elijah Moore | 2025 | 25 | BUF | WR | 9 | 2 | 6 | 24 | 1 | 11 | 4.0 | 2.7 | 0 |
| 407 | Trent Edwards | 2010 | 27 | BUF | QB | 2 | 2 | 5 | 24 | 0 | 8 | 4.8 | 12.0 | 0 |
| 408 | Eric Moulds* | 2000 | 27 | BUF | WR | 16 | 16 | 2 | 24 | 0 | 20 | 12.0 | 1.5 | 1 |
| 409 | Booker Moore | 1985 | 26 | BUF | FB | 16 | 6 | 15 | 23 | 1 | 4 | 1.5 | 1.4 | 1 |
| 410 | Todd Collins | 1995 | 24 | BUF | QB | 7 | 1 | 9 | 23 | 0 | 10 | 2.6 | 3.3 | 0 |
| 411 | Nathan Peterman | 2017 | 23 | BUF | QB | 4 | 2 | 7 | 23 | 0 | 9 | 3.3 | 5.8 | 2 |
| 412 | Roland Hooks | 1982 | 29 | BUF | RB | 6 | 0 | 5 | 23 | 0 | 9 | 4.6 | 3.8 | 0 |
| 413 | Roscoe Parrish | 2010 | 28 | BUF | WR | 8 | 6 | 3 | 23 | 0 | 13 | 7.7 | 2.9 | 1 |
| 414 | Andre Reed* | 1990 | 26 | BUF | WR | 16 | 16 | 3 | 23 | 0 | 26 | 7.7 | 1.4 | 1 |
| 415 | Brian Moorman | 2004 | 28 | BUF | P | 16 | 0 | 2 | 23 | 0 | 34 | 11.5 | 1.4 | 2 |
| 416 | Don Beebe | 1990 | 26 | BUF | WR | 12 | 4 | 1 | 23 | 0 | 23 | 23.0 | 1.9 | 0 |
| 417 | Joe Dufek | 1984 | 23 | BUF | QB | 5 | 5 | 9 | 22 | 1 | 13 | 2.4 | 4.4 | 1 |
| 418 | EJ Manuel | 2016 | 26 | BUF | QB | 6 | 1 | 8 | 22 | 0 | 8 | 2.8 | 3.7 | 2 |
| 419 | Andre Reed | 1996 | 32 | BUF | WR | 16 | 16 | 8 | 22 | 0 | 13 | 2.8 | 1.4 | 1 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 420 | Xavier Omon | 2009 | 24 | BUF | RB | 5 | 0 | 5 | 22 | 0 | 7 | 4.4 | 4.4 | 0 |
| 421 | Lee Evans | 2008 | 27 | BUF | WR | 16 | 16 | 1 | 22 | 0 | 22 | 22.0 | 1.4 | 2 |
| 422 | Tommy O'Connell | 1960 | 30 | BUF | QB | 14 | 7 | 16 | 21 | 1 | 12 | 1.3 | 1.5 | 2 |
| 423 | Andre Reed* | 1993 | 29 | BUF | WR | 15 | 15 | 9 | 21 | 0 | 15 | 2.3 | 1.4 | 3 |
| 424 | Matt Kofler | 1982 | 23 | BUF | QB | 4 | 0 | 2 | 21 | 0 | 12 | 10.5 | 5.3 | 0 |
| 425 | Paul Maguire* | 1965 | 27 | BUF | P | 14 | 0 | 1 | 21 | 0 | 21 | 21.0 | 1.5 | 1 |
| 426 | Brian Moorman | 2003 | 27 | BUF | P | 16 | 0 | 1 | 21 | 0 | 21 | 21.0 | 1.3 | 1 |
| 427 | Jim Kelly | 1995 | 35 | BUF | QB | 15 | 15 | 17 | 20 | 0 | 17 | 1.2 | 1.3 | 7 |
| 428 | Gary Marangi | 1974 | 22 | BUF | QB | 3 | 0 | 4 | 20 | 0 | 16 | 5.0 | 6.7 | 2 |
| 429 | Pete Van Valkenberg | 1973 | 23 | BUF | RB | 13 | 0 | 2 | 20 | 0 | 12 | 10.0 | 1.5 | 0 |
| 430 | Elbert Dubenion* | 1964 | 31 | BUF | FL | 14 | 13 | 1 | 20 | 0 | 20 | 20.0 | 1.4 | 0 |
| 431 | Leo Hart | 1972 | 23 | BUF | QB | 2 | 1 | 5 | 19 | 0 | 16 | 3.8 | 9.5 | 2 |
| 432 | Eric Moulds | 2004 | 31 | BUF | WR | 16 | 16 | 5 | 19 | 0 | 12 | 3.8 | 1.2 | 1 |
| 433 | Mike Taliaferro | 1972 | 31 | BUF | QB | 5 | 0 | 5 | 19 | 0 | 14 | 3.8 | 3.8 | 1 |
| 434 | Joe Auer | 1965 | 24 | BUF | RB | 5 | 0 | 3 | 19 | 0 | 14 | 6.3 | 3.8 | 0 |
| 435 | Marlin Briscoe* | 1970 | 25 | BUF | WR | 14 | 14 | 3 | 19 | 0 | 11 | 6.3 | 1.4 | 3 |
| 436 | Roscoe Parrish | 2007 | 25 | BUF | WR | 16 | 3 | 3 | 19 | 1 | 24 | 6.3 | 1.2 | 1 |
| 437 | Quinton Ganther | 2010 | 26 | BUF | RB | 8 | 0 | 9 | 18 | 0 | 11 | 2.0 | 2.3 | 0 |
| 438 | Larry Kinnebrew | 1990 | 31 | BUF | RB | 2 | 0 | 9 | 18 | 1 | 4 | 2.0 | 9.0 | 0 |
| 439 | Fred Brown | 1963 | 25 | BUF | HB | 4 | 1 | 6 | 18 | 1 | 8 | 3.0 | 4.5 | 0 |
| 440 | Peerless Price | 2006 | 30 | BUF | WR | 16 | 15 | 5 | 18 | 0 | 9 | 3.6 | 1.1 | 1 |
| 441 | Robb Riddick | 1983 | 26 | BUF | RB | 16 | 0 | 4 | 18 | 0 | 12 | 4.5 | 1.1 | 7 |
| 442 | Gary Wilkins | 1986 | 23 | BUF | TE | 16 | 2 | 3 | 18 | 0 | 11 | 6.0 | 1.1 | 0 |
| 443 | Spike Jones | 1972 | 25 | BUF | P | 14 | 0 | 2 | 18 | 0 | 10 | 9.0 | 1.3 | 1 |
| 444 | Roscoe Parrish | 2006 | 24 | BUF | WR | 16 | 1 | 2 | 18 | 0 | 11 | 9.0 | 1.1 | 2 |
| 445 | Jerry Butler* | 1980 | 23 | BUF | WR | 16 | 16 | 1 | 18 | 0 | 18 | 18.0 | 1.1 | 0 |
| 446 | Frank Summers | 2014 | 29 | BUF | RB | 10 | 6 | 6 | 17 | 1 | 4 | 2.8 | 1.7 | 0 |
| 447 | Willie Jones | 1962 | 23 | BUF | FB | 10 | 0 | 4 | 17 | 0 | 10 | 4.3 | 1.7 | 2 |
| 448 | Jeff Tuel | 2013 | 22 | BUF | QB | 2 | 1 | 3 | 17 | 0 | 14 | 5.7 | 8.5 | 0 |
| 449 | Mark Brammer | 1981 | 23 | BUF | TE | 16 | 16 | 2 | 17 | 0 | 11 | 8.5 | 1.1 | 3 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 450 | Antonio Brown | 2003 | 25 | BUF | WR | 16 | 0 | 1 | 17 | 0 | 17 | 17.0 | 1.1 | 1 |
| 451 | Al Edwards | 1991 | 24 | BUF | WR | 16 | 5 | 1 | 17 | 0 | 17 | 17.0 | 1.1 | 2 |
| 452 | Tim Tindale | 1995 | 24 | BUF | FB | 16 | 0 | 5 | 16 | 0 | 6 | 3.2 | 1.0 | 0 |
| 453 | Elbert Dubenion | 1966 | 33 | BUF | FL | 14 | 14 | 3 | 16 | 0 | 17 | 5.3 | 1.1 | 0 |
| 454 | Robert Woods | 2013 | 21 | BUF | WR | 14 | 14 | 2 | 16 | 0 | 13 | 8.0 | 1.1 | 0 |
| 455 | Colton Schmidt | 2016 | 26 | BUF | P | 16 | 0 | 1 | 16 | 0 | 16 | 16.0 | 1.0 | 1 |
| 456 | Johnny Green | 1961 | 24 | BUF | QB | 8 | 6 | 14 | 15 | 1 | 14 | 1.1 | 1.9 | 4 |
| 457 | Richie Lucas | 1961 | 23 | BUF | QB | 8 | 2 | 10 | 15 | 0 | 9 | 1.5 | 1.9 | 1 |
| 458 | Vince Ferragamo | 1985 | 31 | BUF | QB | 10 | 9 | 8 | 15 | 1 | 5 | 1.9 | 1.5 | 1 |
| 459 | Arthur Whittington | 1982 | 27 | BUF | RB | 2 | 0 | 7 | 15 | 0 | 4 | 2.1 | 7.5 | 2 |
| 460 | J.P. Losman | 2004 | 23 | BUF | QB | 4 | 0 | 2 | 15 | 0 | 10 | 7.5 | 3.8 | 1 |
| 461 | Kyle Orton | 2014 | 32 | BUF | QB | 12 | 12 | 15 | 14 | 1 | 10 | 0.9 | 1.2 | 3 |
| 462 | Dan Darragh | 1969 | 23 | BUF | QB | 3 | 2 | 6 | 14 | 0 | 8 | 2.3 | 4.7 | 2 |
| 463 | Curtis Samuel | 2024 | 28 | BUF | WR | 14 | 2 | 5 | 14 | 0 | 7 | 2.8 | 1.0 | 0 |
| 464 | T.J. Graham | 2013 | 24 | BUF | WR | 16 | 6 | 4 | 14 | 0 | 14 | 3.5 | 0.9 | 1 |
| 465 | Brian Moorman | 2007 | 31 | BUF | P | 16 | 0 | 4 | 14 | 0 | 10 | 3.5 | 0.9 | 1 |
| 466 | Willie Ross | 1964 | 23 | BUF | FB | 12 | 0 | 4 | 14 | 1 | 12 | 3.5 | 1.2 | 0 |
| 467 | Tom Sherman | 1969 | 24 | BUF | QB | 1 | 0 | 2 | 14 | 0 | 10 | 7.0 | 14.0 | 0 |
| 468 | Reuben Gant | 1978 | 26 | BUF | TE | 16 | 16 | 1 | 14 | 0 | 14 | 14.0 | 0.9 | 1 |
| 469 | Ryan Neufeld | 2003 | 28 | BUF | TE | 16 | 1 | 1 | 14 | 0 | 14 | 14.0 | 0.9 | 0 |
| 470 | Jerome Felton | 2016 | 30 | BUF | RB | 15 | 4 | 8 | 13 | 0 | 6 | 1.6 | 0.9 | 0 |
| 471 | Bo Cornell | 1973 | 24 | BUF | RB | 14 | 0 | 4 | 13 | 0 | 7 | 3.3 | 0.9 | 0 |
| 472 | Josh Reed | 2006 | 26 | BUF | WR | 13 | 1 | 4 | 13 | 0 | 15 | 3.3 | 1.0 | 0 |
| 473 | Marquise Goodwin | 2013 | 23 | BUF | WR | 12 | 1 | 3 | 13 | 0 | 17 | 4.3 | 1.1 | 1 |
| 474 | Jerry Butler | 1979 | 22 | BUF | WR | 13 | 13 | 2 | 13 | 0 | 12 | 6.5 | 1.0 | 1 |
| 475 | Rick Partridge | 1987 | 30 | BUF | P | 3 | 0 | 1 | 13 | 0 | 13 | 13.0 | 4.3 | 0 |
| 476 | Kevin Williams | 1999 | 28 | BUF | WR | 16 | 0 | 1 | 13 | 0 | 13 | 13.0 | 0.8 | 0 |
| 477 | Kelly Holcomb | 2005 | 32 | BUF | QB | 10 | 8 | 18 | 11 | 1 | 8 | 0.6 | 1.1 | 13 |
| 478 | Dan Darragh | 1968 | 22 | BUF | QB | 11 | 7 | 13 | 11 | 0 | 8 | 0.8 | 1.0 | 7 |
| 479 | Willie Totten | 1987 | 25 | BUF | QB | 2 | 1 | 12 | 11 | 0 | 7 | 0.9 | 5.5 | 9 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 480 | Andre Reed | 1997 | 33 | BUF | WR | 15 | 15 | 3 | 11 | 0 | 9 | 3.7 | 0.7 | 1 |
| 481 | Van Williams | 1983 | 24 | BUF | RB | 16 | 1 | 3 | 11 | 0 | 5 | 3.7 | 0.7 | 2 |
| 482 | Don Beebe | 1994 | 30 | BUF | WR | 13 | 11 | 2 | 11 | 0 | 6 | 5.5 | 0.8 | 3 |
| 483 | Paul Costa | 1968 | 27 | BUF | TE | 14 | 13 | 2 | 11 | 1 | 6 | 5.5 | 0.8 | 0 |
| 484 | Anthony Hutchison | 1985 | 24 | BUF | RB | 5 | 0 | 2 | 11 | 0 | 7 | 5.5 | 2.2 | 0 |
| 485 | Jonathan Smith | 2004 | 23 | BUF | WR | 9 | 0 | 2 | 11 | 0 | 8 | 5.5 | 1.2 | 0 |
| 486 | Percy Harvin | 2016 | 28 | BUF | WR | 2 | 1 | 1 | 11 | 0 | 11 | 11.0 | 5.5 | 0 |
| 487 | J.D. Hill* | 1972 | 24 | BUF | WR | 14 | 14 | 1 | 11 | 0 | 11 | 11.0 | 0.8 | 1 |
| 488 | Chris Mohr | 1992 | 26 | BUF | P | 15 | 0 | 1 | 11 | 0 | 11 | 11.0 | 0.7 | 0 |
| 489 | Bruce King | 1986 | 23 | BUF | RB | 5 | 1 | 4 | 10 | 0 | 7 | 2.5 | 2.0 | 0 |
| 490 | Josh Reed | 2007 | 27 | BUF | WR | 15 | 9 | 4 | 10 | 0 | 12 | 2.5 | 0.7 | 0 |
| 491 | Travis Brown | 2001 | 24 | BUF | QB | 1 | 0 | 1 | 10 | 0 | 10 | 10.0 | 10.0 | 1 |
| 492 | Stevie Johnson | 2013 | 27 | BUF | WR | 12 | 12 | 1 | 10 | 0 | 10 | 10.0 | 0.8 | 1 |
| 493 | Ed Rutkowski | 1966 | 25 | BUF | SE | 14 | 0 | 1 | 10 | 0 | 10 | 10.0 | 0.7 | 1 |
| 494 | Khalil Shakir | 2023 | 23 | BUF | WR | 17 | 10 | 1 | 10 | 0 | 10 | 10.0 | 0.6 | 1 |
| 495 | Isaiah McKenzie | 2020 | 25 | BUF | WR | 16 | 7 | 10 | 9 | 0 | 14 | 0.9 | 0.6 | 0 |
| 496 | Jack Spikes | 1967 | 30 | BUF | FB | 7 | 1 | 4 | 9 | 0 | 6 | 2.3 | 1.3 | 0 |
| 497 | Steve Jones | 1973 | 22 | BUF | RB | 11 | 0 | 3 | 9 | 0 | 7 | 3.0 | 0.8 | 0 |
| 498 | Art Baker | 1962 | 25 | BUF | FB | 3 | 0 | 2 | 9 | 0 | 7 | 4.5 | 3.0 | 0 |
| 499 | Clint Haslerig | 1975 | 23 | BUF | RB | 3 | 0 | 2 | 9 | 0 | 6 | 4.5 | 3.0 | 0 |
| 500 | Roscoe Parrish | 2008 | 26 | BUF | WR | 13 | 1 | 2 | 9 | 0 | 9 | 4.5 | 0.7 | 2 |
| 501 | Keon Coleman | 2024 | 21 | BUF | WR | 13 | 12 | 1 | 9 | 0 | 9 | 9.0 | 0.7 | 0 |
| 502 | Patrick DiMarco | 2018 | 29 | BUF | FB | 16 | 5 | 1 | 9 | 0 | 9 | 9.0 | 0.6 | 0 |
| 503 | Dawson Knox | 2019 | 23 | BUF | TE | 15 | 11 | 1 | 9 | 0 | 9 | 9.0 | 0.6 | 0 |
| 504 | Ted Koy | 1972 | 25 | BUF | RB | 14 | 0 | 1 | 9 | 0 | 9 | 9.0 | 0.6 | 0 |
| 505 | Steve Tasker* | 1992 | 30 | BUF | WR | 15 | 2 | 1 | 9 | 0 | 9 | 9.0 | 0.6 | 0 |
| 506 | Daryle Lamonica | 1963 | 22 | BUF | QB | 14 | 2 | 9 | 8 | 0 | 7 | 0.9 | 0.6 | 1 |
| 507 | Jason Bratton | 1996 | 24 | BUF | RB | 2 | 0 | 4 | 8 | 0 | 5 | 2.0 | 4.0 | 0 |
| 508 | Marquise Goodwin | 2014 | 24 | BUF | WR | 10 | 0 | 3 | 8 | 0 | 12 | 2.7 | 0.8 | 1 |
| 509 | Glenn Bass | 1961 | 22 | BUF | LE | 14 | 12 | 2 | 8 | 0 | 16 | 4.0 | 0.6 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 510 | Darick Holmes | 1998 | 27 | BUF | RB | 3 | 0 | 2 | 8 | 0 | 5 | 4.0 | 2.7 | 0 |
| 511 | Sammy Watkins | 2014 | 21 | BUF | WR | 16 | 16 | 2 | 8 | 0 | 5 | 4.0 | 0.5 | 1 |
| 512 | Mark Brammer | 1980 | 22 | BUF | TE | 16 | 5 | 1 | 8 | 0 | 8 | 8.0 | 0.5 | 0 |
| 513 | Al Edwards | 1992 | 25 | BUF | WR | 7 | 0 | 1 | 8 | 0 | 8 | 8.0 | 1.1 | 1 |
| 514 | Tyler Thigpen | 2011 | 27 | BUF | QB | 3 | 0 | 1 | 8 | 0 | 8 | 8.0 | 2.7 | 0 |
| 515 | Joe Burns | 2002 | 23 | BUF | RB | 10 | 0 | 5 | 7 | 0 | 6 | 1.4 | 0.7 | 0 |
| 516 | Bill Brooks | 1995 | 31 | BUF | WR | 15 | 10 | 3 | 7 | 0 | 9 | 2.3 | 0.5 | 0 |
| 517 | Patrick DiMarco | 2019 | 30 | BUF | FB | 16 | 4 | 3 | 7 | 0 | 4 | 2.3 | 0.4 | 0 |
| 518 | Reggie Gilliam | 2024 | 27 | BUF | FB | 15 | 0 | 3 | 7 | 0 | 4 | 2.3 | 0.5 | 0 |
| 519 | Manch Wheeler | 1962 | 23 | BUF | QB | 4 | 0 | 3 | 7 | 0 | 7 | 2.3 | 1.8 | 0 |
| 520 | John Brown | 2019 | 29 | BUF | WR | 15 | 15 | 2 | 7 | 0 | 4 | 3.5 | 0.5 | 0 |
| 521 | Billy Joe Hobert | 1997 | 26 | BUF | QB | 2 | 0 | 2 | 7 | 0 | 7 | 3.5 | 3.5 | 1 |
| 522 | Eric Moulds* | 2002 | 29 | BUF | WR | 16 | 15 | 1 | 7 | 0 | 7 | 7.0 | 0.4 | 1 |
| 523 | Andre Roberts* | 2019 | 31 | BUF | WR | 13 | 0 | 1 | 7 | 0 | 7 | 7.0 | 0.5 | 1 |
| 524 | Frank Reich | 1991 | 30 | BUF | QB | 16 | 1 | 13 | 6 | 0 | 8 | 0.5 | 0.4 | 0 |
| 525 | Daryle Lamonica | 1966 | 25 | BUF | QB | 14 | 0 | 9 | 6 | 1 | 14 | 0.7 | 0.4 | 2 |
| 526 | Mitchell Trubisky | 2025 | 31 | BUF | QB | 4 | 0 | 9 | 6 | 0 | 9 | 0.7 | 1.5 | 0 |
| 527 | Wayne Crow | 1963 | 25 | BUF | HB | 5 | 1 | 6 | 6 | 0 | 7 | 1.0 | 1.2 | 0 |
| 528 | Dan Manucci | 1987 | 30 | BUF | QB | 3 | 1 | 4 | 6 | 0 | 9 | 1.5 | 2.0 | 1 |
| 529 | Wayne Mosley | 1974 | 22 | BUF | RB | 3 | 0 | 2 | 6 | 0 | 4 | 3.0 | 2.0 | 0 |
| 530 | Keith Ellison | 2008 | 24 | BUF | LLB | 16 | 14 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0 |
| 531 | Tony Hunter | 1984 | 24 | BUF | TE | 11 | 9 | 1 | 6 | 0 | 6 | 6.0 | 0.5 | 1 |
| 532 | Lonnie Johnson | 1997 | 26 | BUF | TE | 16 | 16 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 2 |
| 533 | Stevie Johnson | 2008 | 22 | BUF | WR | 11 | 1 | 1 | 6 | 0 | 6 | 6.0 | 0.5 | 0 |
| 534 | Paul Maguire | 1968 | 30 | BUF | P | 14 | 0 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0 |
| 535 | Lou Piccone | 1977 | 28 | BUF | WR | 14 | 10 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0 |
| 536 | George Wilson | 2011 | 30 | BUF | SS | 13 | 13 | 1 | 6 | 0 | 6 | 6.0 | 0.5 | 0 |
| 537 | Robert Woods | 2016 | 24 | BUF | WR | 13 | 10 | 1 | 6 | 0 | 6 | 6.0 | 0.5 | 0 |
| 538 | Xavier Omon | 2008 | 23 | BUF | RB | 2 | 0 | 6 | 5 | 0 | 2 | 0.8 | 2.5 | 0 |
| 539 | Corey McIntyre | 2010 | 31 | BUF | FB | 16 | 7 | 4 | 5 | 1 | 2 | 1.3 | 0.3 | 1 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 540 | Dennis Johnson | 1979 | 23 | BUF | FB | 3 | 0 | 3 | 5 | 0 | 2 | 1.7 | 1.7 | 0 |
| 541 | Bob Chandler | 1975 | 26 | BUF | WR | 14 | 13 | 2 | 5 | 0 | 5 | 2.5 | 0.4 | 0 |
| 542 | Sammy Morris | 2002 | 25 | BUF | RB | 16 | 0 | 2 | 5 | 0 | 5 | 2.5 | 0.3 | 0 |
| 543 | Pooh Bear Williams | 1998 | 23 | BUF | RB | 3 | 0 | 2 | 5 | 0 | 3 | 2.5 | 1.7 | 0 |
| 544 | Travis Brown | 2003 | 26 | BUF | QB | 2 | 0 | 1 | 5 | 0 | 5 | 5.0 | 2.5 | 0 |
| 545 | Stefon Diggs* | 2023 | 30 | BUF | WR | 17 | 17 | 1 | 5 | 0 | 5 | 5.0 | 0.3 | 2 |
| 546 | T.J. Graham | 2012 | 23 | BUF | TE | 15 | 11 | 1 | 5 | 0 | 5 | 5.0 | 0.3 | 0 |
| 547 | David Humm | 1980 | 28 | BUF | QB | 16 | 0 | 1 | 5 | 0 | 5 | 5.0 | 0.3 | 1 |
| 548 | Khalil Shakir | 2025 | 25 | BUF | WR | 16 | 10 | 1 | 5 | 0 | 5 | 5.0 | 0.3 | 1 |
| 549 | Reggie Gilliam | 2025 | 28 | BUF | FB | 17 | 2 | 2 | 4 | 0 | 5 | 2.0 | 0.2 | 0 |
| 550 | Duke Johnson | 2022 | 29 | BUF | RB | 1 | 0 | 2 | 4 | 0 | 4 | 2.0 | 4.0 | 0 |
| 551 | Ray-Ray McCloud | 2018 | 22 | BUF | WR | 10 | 1 | 2 | 4 | 0 | 7 | 2.0 | 0.4 | 2 |
| 552 | Brian McClure | 1987 | 24 | BUF | QB | 1 | 1 | 2 | 4 | 0 | 3 | 2.0 | 4.0 | 0 |
| 553 | Roscoe Parrish | 2009 | 27 | BUF | WR | 12 | 0 | 2 | 4 | 0 | 9 | 2.0 | 0.3 | 5 |
| 554 | Khalil Shakir | 2024 | 24 | BUF | WR | 15 | 9 | 2 | 4 | 0 | 2 | 2.0 | 0.3 | 1 |
| 555 | Ken Simonton | 2003 | 24 | BUF | RB | 2 | 0 | 2 | 4 | 0 | 2 | 2.0 | 2.0 | 0 |
| 556 | Nate Turner | 1994 | 25 | BUF | TE | 13 | 0 | 2 | 4 | 0 | 4 | 2.0 | 0.3 | 0 |
| 557 | Chris Hogan | 2015 | 28 | BUF | WR | 16 | 4 | 1 | 4 | 0 | 4 | 4.0 | 0.3 | 0 |
| 558 | Nick Mike-Mayer | 1979 | 29 | BUF | K | 13 | 0 | 1 | 4 | 0 | 4 | 4.0 | 0.3 | 0 |
| 559 | Ronnie Wingo | 2013 | 22 | BUF | RB | 2 | 0 | 1 | 4 | 0 | 4 | 4.0 | 2.0 | 0 |
| 560 | Frank Reich | 1994 | 33 | BUF | QB | 16 | 2 | 6 | 3 | 0 | 5 | 0.5 | 0.2 | 1 |
| 561 | Reggie Gilliam | 2021 | 24 | BUF | FB | 16 | 5 | 3 | 3 | 0 | 2 | 1.0 | 0.2 | 0 |
| 562 | Eric Moulds | 2001 | 28 | BUF | WR | 16 | 16 | 3 | 3 | 0 | 6 | 1.0 | 0.2 | 1 |
| 563 | Senorise Perry | 2019 | 28 | BUF | RB | 11 | 0 | 3 | 3 | 0 | 6 | 1.0 | 0.3 | 0 |
| 564 | Robb Riddick | 1984 | 27 | BUF | RB | 16 | 0 | 3 | 3 | 0 | 6 | 1.0 | 0.2 | 1 |
| 565 | Cierre Wood | 2015 | 24 | BUF | RB | 2 | 0 | 2 | 3 | 0 | 3 | 1.5 | 1.5 | 0 |
| 566 | Byron Franklin | 1983 | 25 | BUF | WR | 15 | 5 | 1 | 3 | 0 | 3 | 3.0 | 0.2 | 0 |
| 567 | Sam Gash | 2003 | 34 | BUF | FB | 16 | 10 | 1 | 3 | 0 | 3 | 3.0 | 0.2 | 1 |
| 568 | Darrell Harper | 1960 | 22 | BUF | HB | 4 | 0 | 1 | 3 | 0 | 3 | 3.0 | 0.8 | 0 |
| 569 | Robert Holt | 1982 | 23 | BUF | WR | 7 | 0 | 1 | 3 | 0 | 3 | 3.0 | 0.4 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 570 | Naaman Roosevelt | 2010 | 23 | BUF | WR | 6 | 1 | 1 | 3 | 0 | 3 | 3.0 | 0.5 | 0 |
| 571 | Dennis Shaw | 1973 | 26 | BUF | QB | 4 | 0 | 4 | 2 | 0 | 1 | 0.5 | 0.5 | 2 |
| 572 | Carey Henley | 1962 | 26 | BUF | HB | 1 | 0 | 3 | 2 | 0 | 4 | 0.7 | 2.0 | 0 |
| 573 | Brian Moorman*+ | 2006 | 30 | BUF | P | 16 | 0 | 2 | 2 | 0 | 2 | 1.0 | 0.1 | 1 |
| 574 | Shaud Williams | 2006 | 26 | BUF | RB | 5 | 0 | 2 | 2 | 0 | 2 | 1.0 | 0.4 | 0 |
| 575 | Jehuu Caulcrick | 2010 | 27 | BUF | RB | 2 | 0 | 1 | 2 | 0 | 2 | 2.0 | 1.0 | 0 |
| 576 | Jerome Felton | 2015 | 29 | BUF | RB | 16 | 8 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 0 |
| 577 | Willmer Fowler | 1961 | 24 | BUF | HB | 2 | 1 | 1 | 2 | 0 | 2 | 2.0 | 1.0 | 0 |
| 578 | J.D. Hill | 1971 | 23 | BUF | WR | 5 | 5 | 1 | 2 | 0 | 2 | 2.0 | 0.4 | 0 |
| 579 | Donald Jones | 2011 | 24 | BUF | WR | 8 | 7 | 1 | 2 | 0 | 2 | 2.0 | 0.3 | 0 |
| 580 | Wayne Patrick | 1968 | 22 | BUF | RB | 3 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.7 | 0 |
| 581 | Charley Warner* | 1965 | 25 | BUF | LCB | 14 | 5 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 1 |
| 582 | Mitchell Trubisky | 2024 | 30 | BUF | QB | 9 | 0 | 17 | 1 | 0 | 8 | 0.1 | 0.1 | 1 |
| 583 | Donald Jones | 2010 | 23 | BUF | WR | 15 | 5 | 3 | 1 | 0 | 2 | 0.3 | 0.1 | 0 |
| 584 | Brian Moorman | 2010 | 34 | BUF | P | 16 | 0 | 2 | 1 | 0 | 1 | 0.5 | 0.1 | 0 |
| 585 | Jerry Butler | 1981 | 24 | BUF | WR | 16 | 16 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 2 |
| 586 | Stefon Diggs*+ | 2020 | 27 | BUF | WR | 16 | 15 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 587 | J.D. Hill | 1975 | 27 | BUF | WR | 14 | 13 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 588 | Dick Hudson | 1964 | 24 | BUF | RT | 14 | 14 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 589 | Eric Moulds | 1999 | 26 | BUF | WR | 14 | 14 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 1 |
| 590 | Andre Reed | 1987 | 23 | BUF | WR | 12 | 12 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 591 | Jonathan Smith | 2005 | 24 | BUF | WR | 7 | 1 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 1 |
| 592 | Sammy Watkins | 2015 | 22 | BUF | WR | 13 | 13 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 593 | Kyle Williams | 2017 | 34 | BUF | LDT | 16 | 16 | 1 | 1 | 1 | 1 | 1.0 | 0.1 | 0 |
| 594 | Case Keenum | 2022 | 34 | BUF | QB | 2 | 0 | 5 | 0 | 0 | 4 | 0.0 | 0.0 | 0 |
| 595 | Deonte Harty | 2023 | 26 | BUF | WR | 16 | 1 | 4 | 0 | 0 | 4 | 0.0 | 0.0 | 2 |
| 596 | Kerry Porter | 1987 | 23 | BUF | RB | 6 | 0 | 2 | 0 | 0 | 1 | 0.0 | 0.0 | 0 |
| 597 | Marv Bateman | 1977 | 27 | BUF | P | 14 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 598 | Corey Bojorquez | 2018 | 22 | BUF | P | 8 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 2 |
| 599 | Jim Braxton | 1976 | 27 | BUF | RB | 1 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 600 | Bob Chandler | 1976 | 27 | BUF | WR | 14 | 14 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 3 |
| 601 | Kaelin Clay | 2017 | 25 | BUF | WR | 4 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 602 | Gabe Davis | 2020 | 21 | BUF | WR | 16 | 11 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 603 | Emmett Edwards | 1976 | 24 | BUF | WR | 6 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 604 | Mike Franckowiak | 1977 | 24 | BUF | RB | 13 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 605 | Spike Jones | 1973 | 26 | BUF | P | 14 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 606 | Zay Jones | 2018 | 23 | BUF | WR | 16 | 15 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 607 | John Kidd | 1986 | 25 | BUF | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 608 | Chris Mohr | 1997 | 31 | BUF | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 609 | Chris Mohr | 1999 | 33 | BUF | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 610 | Brian Moorman | 2001 | 25 | BUF | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 611 | Frank Reich | 1986 | 25 | BUF | QB | 3 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 612 | Colton Schmidt | 2015 | 25 | BUF | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 613 | Daimon Shelton | 2005 | 33 | BUF | FB | 16 | 11 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 614 | Bruce Smith | 1985 | 22 | BUF | RDE | 16 | 13 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 615 | Robert Woods | 2015 | 23 | BUF | WR | 14 | 9 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 2 |
| 616 | Gene Donaldson | 1967 | 25 | BUF | RB | 2 | 0 | 3 | -1 | 0 | 2 | -0.3 | -0.5 | 0 |
| 617 | Andre Reed | 1985 | 21 | BUF | WR | 16 | 15 | 3 | -1 | 1 | 14 | -0.3 | -0.1 | 2 |
| 618 | Josh Reed | 2004 | 24 | BUF | WR | 12 | 1 | 2 | -1 | 0 | 6 | -0.5 | -0.1 | 0 |
| 619 | Derek Anderson | 2018 | 35 | BUF | QB | 2 | 2 | 1 | -1 | 0 | -1 | -1.0 | -0.5 | 3 |
| 620 | Russell Copeland | 1995 | 24 | BUF | WR | 16 | 15 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 1 |
| 621 | Cardale Jones | 2016 | 24 | BUF | QB | 1 | 0 | 1 | -1 | 0 | -1 | -1.0 | -1.0 | 0 |
| 622 | Terrelle Pryor | 2018 | 29 | BUF | WR | 2 | 1 | 1 | -1 | 0 | -1 | -1.0 | -0.5 | 0 |
| 623 | Marcus Thigpen | 2015 | 29 | BUF | RB | 8 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 2 |
| 624 | Tyler Thigpen | 2012 | 28 | BUF | QB | 4 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.3 | 0 |
| 625 | Alex Van Pelt | 1998 | 28 | BUF | QB | 1 | 0 | 1 | -1 | 0 | -1 | -1.0 | -1.0 | 0 |
| 626 | Alex Van Pelt | 1999 | 29 | BUF | QB | 1 | 0 | 1 | -1 | 0 | -1 | -1.0 | -1.0 | 0 |
| 627 | Matt Barkley | 2018 | 28 | BUF | QB | 1 | 1 | 3 | -2 | 0 | 0 | -0.7 | -2.0 | 0 |
| 628 | Patrick DiMarco | 2017 | 28 | BUF | FB | 16 | 9 | 2 | -2 | 0 | 0 | -1.0 | -0.1 | 0 |
| 629 | Roscoe Parrish | 2005 | 23 | BUF | WR | 10 | 1 | 2 | -2 | 0 | 4 | -1.0 | -0.2 | 2 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 630 | Gabe Davis | 2023 | 24 | BUF | WR | 17 | 17 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 1 |
| 631 | John Fina | 1993 | 24 | BUF | LT | 16 | 16 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 0 |
| 632 | Robert Hicks | 1999 | 25 | BUF | RT | 14 | 14 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 0 |
| 633 | Matt Robinson | 1981 | 26 | BUF | QB | 15 | 0 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 1 |
| 634 | Reggie Bush | 2016 | 31 | BUF | RB | 13 | 0 | 12 | -3 | 1 | 5 | -0.3 | -0.2 | 1 |
| 635 | Nyheim Hines | 2022 | 26 | BUF | RB | 9 | 1 | 6 | -3 | 0 | 3 | -0.5 | -0.3 | 1 |
| 636 | Brian Brohm | 2009 | 24 | BUF | QB | 2 | 1 | 3 | -3 | 0 | -1 | -1.0 | -1.5 | 0 |
| 637 | Frank Reich | 1988 | 27 | BUF | QB | 3 | 0 | 3 | -3 | 0 | -1 | -1.0 | -1.0 | 0 |
| 638 | Shane Matthews | 2004 | 34 | BUF | QB | 3 | 0 | 2 | -3 | 0 | -1 | -1.5 | -1.0 | 0 |
| 639 | Davis Webb | 2021 | 26 | BUF | QB | 1 | 0 | 2 | -3 | 0 | -1 | -1.5 | -3.0 | 0 |
| 640 | Stefon Diggs* | 2022 | 29 | BUF | WR | 16 | 16 | 1 | -3 | 0 | -3 | -3.0 | -0.2 | 1 |
| 641 | Stan Gelbaugh | 1989 | 27 | BUF | QB | 1 | 0 | 1 | -3 | 0 | -3 | -3.0 | -3.0 | 0 |
| 642 | Justin Jenkins | 2009 | 29 | BUF | WR | 12 | 0 | 1 | -3 | 0 | -3 | -3.0 | -0.3 | 0 |
| 643 | Billy Masters | 1969 | 25 | BUF | TE | 14 | 14 | 1 | -3 | 0 | -3 | -3.0 | -0.2 | 1 |
| 644 | Josh Reed | 2005 | 25 | BUF | WR | 16 | 6 | 1 | -3 | 0 | -3 | -3.0 | -0.2 | 0 |
| 645 | Andre Roberts* | 2020 | 32 | BUF | WR | 15 | 0 | 1 | -3 | 0 | -3 | -3.0 | -0.2 | 3 |
| 646 | Haven Moses | 1968 | 22 | BUF | FL | 14 | 14 | 5 | -4 | 0 | 19 | -0.8 | -0.3 | 0 |
| 647 | Matt Barkley | 2019 | 29 | BUF | QB | 2 | 0 | 2 | -4 | 0 | 0 | -2.0 | -2.0 | 3 |
| 648 | Justin Armour | 1995 | 22 | BUF | WR | 15 | 9 | 4 | -5 | 0 | 6 | -1.3 | -0.3 | 1 |
| 649 | Alex Van Pelt | 1996 | 26 | BUF | QB | 1 | 0 | 3 | -5 | 0 | -1 | -1.7 | -5.0 | 0 |
| 650 | Deonte Thompson | 2017 | 28 | BUF | WR | 11 | 7 | 2 | -5 | 0 | 0 | -2.5 | -0.5 | 0 |
| 651 | Matt Barkley | 2020 | 30 | BUF | QB | 5 | 0 | 6 | -6 | 0 | -1 | -1.0 | -1.2 | 0 |
| 652 | Frank Reich | 1993 | 32 | BUF | QB | 15 | 0 | 6 | -6 | 0 | -1 | -1.0 | -0.4 | 0 |
| 653 | Alex Van Pelt | 2003 | 33 | BUF | QB | 6 | 0 | 4 | -6 | 0 | -1 | -1.5 | -1.0 | 0 |
| 654 | Frank Lewis | 1979 | 32 | BUF | WR | 15 | 15 | 2 | -6 | 0 | -1 | -3.0 | -0.4 | 1 |
| 655 | Don Beebe | 1992 | 28 | BUF | WR | 12 | 8 | 1 | -6 | 0 | -6 | -6.0 | -0.5 | 1 |
| 656 | Walter Broughton | 1986 | 24 | BUF | WR | 8 | 0 | 1 | -6 | 0 | -6 | -6.0 | -0.8 | 5 |
| 657 | Jabari Greer | 2004 | 22 | BUF | DB | 12 | 1 | 1 | -6 | 0 | -6 | -6.0 | -0.5 | 0 |
| 658 | Rod Kush | 1981 | 25 | BUF | DB | 16 | 0 | 1 | -6 | 0 | -6 | -6.0 | -0.4 | 1 |
| 659 | Brian Moorman | 2002 | 26 | BUF | P | 16 | 0 | 1 | -6 | 0 | -6 | -6.0 | -0.4 | 0 |
| Rk | Player | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | ||
| 660 | Russell Copeland | 1994 | 23 | BUF | WR | 15 | 4 | 1 | -7 | 0 | -7 | -7.0 | -0.5 | 0 |
| 661 | Byron Franklin | 1984 | 26 | BUF | WR | 16 | 16 | 1 | -7 | 0 | -7 | -7.0 | -0.4 | 4 |
| 662 | Peerless Price | 1999 | 23 | BUF | WR | 16 | 4 | 1 | -7 | 0 | -7 | -7.0 | -0.4 | 0 |
| 663 | James Harris | 1970 | 23 | BUF | QB | 7 | 0 | 3 | -8 | 0 | 1 | -2.7 | -1.1 | 2 |
| 664 | Andre Reed | 1986 | 22 | BUF | WR | 15 | 15 | 3 | -8 | 0 | 4 | -2.7 | -0.5 | 2 |
| 665 | Dorin Dickerson | 2012 | 24 | BUF | TE | 11 | 0 | 1 | -8 | 0 | -8 | -8.0 | -0.7 | 1 |
| 666 | Frank Reich | 1992 | 31 | BUF | QB | 16 | 0 | 9 | -9 | 0 | 0 | -1.0 | -0.6 | 3 |
| 667 | Ron Jessie | 1980 | 32 | BUF | WR | 16 | 3 | 1 | -9 | 0 | -9 | -9.0 | -0.6 | 0 |
| 668 | Chris Mohr | 1994 | 28 | BUF | P | 16 | 0 | 1 | -9 | 0 | -9 | -9.0 | -0.6 | 0 |
| 669 | Robert Royal | 2006 | 27 | BUF | TE | 16 | 15 | 1 | -9 | 0 | -9 | -9.0 | -0.6 | 0 |
| 670 | Greg Cater | 1980 | 23 | BUF | P | 16 | 0 | 2 | -10 | 0 | -1 | -5.0 | -0.6 | 0 |
| 671 | Byron Franklin | 1981 | 23 | BUF | WR | 13 | 0 | 1 | -11 | 0 | -11 | -11.0 | -0.8 | 2 |
| 672 | Kyle Allen | 2023 | 27 | BUF | QB | 7 | 0 | 13 | -13 | 0 | 0 | -1.0 | -1.9 | 0 |
| 673 | Peerless Price | 2002 | 26 | BUF | WR | 16 | 16 | 3 | -13 | 0 | 1 | -4.3 | -0.8 | 2 |
| 674 | Rusty Jackson | 1978 | 28 | BUF | P | 16 | 0 | 1 | -13 | 0 | -13 | -13.0 | -0.8 | 0 |
| 675 | Bob Chandler | 1973 | 24 | BUF | WR | 14 | 14 | 5 | -14 | 0 | 18 | -2.8 | -1.0 | 2 |
| 676 | Elbert Dubenion | 1967 | 34 | BUF | FL | 12 | 11 | 2 | -17 | 0 | -1 | -8.5 | -1.4 | 0 |
| 677 | Tom Rychlec | 1961 | 27 | BUF | RE | 14 | 4 | 1 | -18 | 0 | -18 | -18.0 | -1.3 | 0 |

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