Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Alex Smith | 23 | 2 | 7 | 94 for 193, 914 yards, 2 td, 4 int, & 13 rushes for 89 yards and 0 td | |
| RB | Frank Gore | 24 | 2 | 15 | 260 rushes for 1,102 yards, 5 td, & 53 catches for 436 yards and 1 td | |
| WR | Arnaz Battle | 27 | 4 | 15 | 50 catches for 600 yards, 5 td, & 4 rushes for 4 yards and 1 td | |
| WR | Darrell Jackson | 29 | 7 | 15 | 46 catches for 497 yards, 3 td | |
| TE | Vernon Davis | 23 | 1 | 14 | 52 catches for 509 yards, 4 td | |
| TE | Delanie Walker | 23 | 1 | 10 | 21 catches for 174 yards, 1 td | |
| LT | Adam Snyder | 25 | 2 | 11 | ||
| LG | Larry Allen | 36 | 13 | 16 | ||
| C | Eric Heitmann | 27 | 5 | 16 | ||
| RG | David Baas | 26 | 2 | 8 | ||
| RT | Joe Staley | 23 | Rook | 16 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Bryant Young | 35 | 13 | 16 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Aubrayo Franklin | 27 | 4 | 13 | ||
| RDE | Marques Douglas | 30 | 7 | 16 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Parys Haralson | 23 | 1 | 11 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Derek Smith | 32 | 10 | 14 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| RILB | Patrick Willis*+ | 22 | Rook | 16 | 4.0 sacks, 0 interceptions, 1 fumble recovered | |
| ROLB | Tully Banta-Cain | 27 | 4 | 10 | 3.5 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Nate Clements | 28 | 6 | 16 | 1.0 sacks, 4 interceptions, 0 fumbles recovered | |
| RCB | Walt Harris | 33 | 11 | 15 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | |
| SS | Michael Lewis | 27 | 5 | 16 | 1.5 sacks, 2 interceptions, 1 fumble recovered | |
| FS | Mark Roman | 30 | 7 | 16 | 0.0 sacks, 0 interceptions, 3 fumbles recovered |
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