Trades
- April 4, 2022: Traded 2022 1st round pick (16th overall subsequently traded , Jahan Dotson), 2022 1st round pick (19th overall, Trevor Penning) and 2022 6th round pick (194th overall, Jordan Jackson) to Saints for 2022 1st round pick (18th overall subsequently traded , Treylon Burks), 2022 3rd round pick (101st overall subsequently traded , Jeremy Ruckert), 2022 7th round pick (237th overall subsequently traded , Chase Lucas), 2023 1st round pick (10th overall subsequently traded , Darnell Wright) and a 2024 2nd round pick
- April 28, 2022: Traded 2022 1st round pick (15th overall, Kenyon Green), 2022 4th round pick (124th overall subsequently traded , Cade York), 2022 5th round pick (162nd overall subsequently traded , Montrell Washington) and 2022 5th round pick (166th overall subsequently traded , Tycen Anderson) to Texans for 2022 1st round pick (13th overall, Jordan Davis)
- April 28, 2022: Traded 2022 1st round pick (18th overall, Treylon Burks) and 2022 3rd round pick (101st overall subsequently traded , Jeremy Ruckert) to Titans for A.J. Brown
- April 30, 2022: Traded 2022 5th round pick (154th overall, Snoop Conner) to Jaguars for 2022 6th round pick (188th overall subsequently traded , Malcolm Rodriguez) and 2022 6th round pick (198th overall, Grant Calcaterra)
- April 30, 2022: Traded 2022 6th round pick (188th overall, Malcolm Rodriguez) and 2022 7th round pick (237th overall, Chase Lucas) to Lions for 2022 6th round pick (181st overall, Kyron Johnson)
- August 15, 2022: Traded JJ Arcega-Whiteside to Seahawks for Ugo Amadi
- August 24, 2022: Traded Ugo Amadi and a 2024 7th round pick to Titans for a 2024 6th round pick
- August 30, 2022: Traded 2023 5th round pick (165th overall subsequently traded , Terell Smith) and a 2024 6th round pick to Saints for C.J. Gardner-Johnson and a 2025 7th round pick
- August 31, 2022: Traded Jalen Reagor to Vikings for 2023 7th round pick (219th overall subsequently traded , Antoine Green) and a 2024 5th round pick
- October 26, 2022: Traded 2023 4th round pick (133rd overall, Tyler Scott) to Bears for Robert Quinn
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