| Offensive Starters | | | | | |
| QB | Eli Manning | 26 | 3 | 16 | 297 for 529, 3,336 yards, 23 td, 20 int, & 29 rushes for 69 yards and 1 td | |
| RB | Brandon Jacobs | 25 | 2 | 9 | 202 rushes for 1,009 yards, 4 td, & 23 catches for 174 yards and 2 td | |
| FB | Madison Hedgecock | 26 | 2 | 9 | 0 rushes for yards, 0 td, & 6 catches for 45 yards and 0 td | |
| WR | Plaxico Burress | 30 | 7 | 16 | 70 catches for 1,025 yards, 12 td | |
| WR | Amani Toomer | 33 | 11 | 15 | 59 catches for 760 yards, 3 td | |
| TE | Jeremy Shockey | 27 | 5 | 14 | 57 catches for 619 yards, 3 td, & 1 rush for 6 yards and 0 td | |
| LT | David Diehl | 27 | 4 | 16 | | |
| LG | Rich Seubert | 28 | 6 | 16 | 1 fumble recovered | |
| C | Shaun O'Hara | 30 | 7 | 16 | | |
| RG | Chris Snee | 25 | 3 | 16 | 1 fumble recovered | |
| RT | Kareem McKenzie | 28 | 6 | 16 | 1 fumble recovered | |
| Defensive Starters | | | | | |
| LDE | Michael Strahan | 36 | 14 | 15 | 9.0 sacks, 0 interceptions, 1 fumble recovered | |
| LDT | Barry Cofield | 23 | 1 | 15 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDT | Fred Robbins | 30 | 7 | 15 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Osi Umenyiora* | 26 | 4 | 16 | 13.0 sacks, 0 interceptions, 2 fumbles recovered | |
| LLB | Mathias Kiwanuka | 24 | 1 | 9 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Antonio Pierce | 29 | 6 | 16 | 1.0 sacks, 1 interception, 2 fumbles recovered | |
| RLB | Kawika Mitchell | 28 | 4 | 16 | 3.5 sacks, 1 interception, 1 fumble recovered | |
| LCB | Aaron Ross | 25 | Rook | 9 | 1.5 sacks, 3 interceptions, 0 fumbles recovered | |
| RCB | Sam Madison | 33 | 10 | 15 | 1.0 sacks, 4 interceptions, 1 fumble recovered | |
| SS | James Butler | 25 | 2 | 12 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| FS | Gibril Wilson | 26 | 3 | 13 | 0.0 sacks, 4 interceptions, 1 fumble recovered | |
Roster